基于“预培其损”理论的中药复方防治反复着床失败研究进展  

Research progress in prevention and treatment of repeated implantation failure by TCM compounds based on"Yu Pei Qi Sun"theory

作　　者：鞠文涵 吴海萃[2] 连方[2] Wenhan Ju;Haicui Wu;Fang Lian(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Reproductive and Genetic,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]山东中医药大学,济南250014 [2]山东中医药大学附属医院生殖与遗传科,济南250011

出　　处：《国际中医中药杂志》2023年第6期788-792,F0003,共6页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81974577,81774355)。

摘　　要：体外受精-胚胎移植(IVF-ET)女性可能经历反复着床失败。在“预培其损”理论指导下,中药复方可在IVF-ET前通过抗氧化应激、改善线粒体功能、减少细胞过度凋亡等途径,提高夫妻双方精卵质量以获取高质量胚胎;可促进血管生成、抗氧化应激、调节雌孕激素受体含量、调节免疫改善女性子宫内膜容受性,以利于胚胎植入;还可在移植后发挥补益脾肾、顾护胎元作用,以助着床,亦可缓解移植时患者的焦虑情绪。Women undergoing in vitro fertilization-embryo transfer(IVF-ET)may experience repeated implantation failure(RIF).Under the guidance of"Yu Pei Qi Sun"theory,Traditional Chinese Medicine(TCM)compounds can improve the quality of sperm and eggs of both husband and wife by anti-oxidative stress,improving mitochondrial function and reducing excessive apoptosis before IVF-ET to obtain high-quality embryos;TCM compounds can also promote angiogenesis,anti-oxidative stress,regulation of estrogen and progesterone receptor content,regulate immunity to improve female endometrial receptivity to facilitate embryo implantation;it can also invigorate the spleen and kidney after transplantation and caring for the fetus to help implantation,as well as alleviate the anxiety of patients during transplantation.

关 键 词：中医妇产科疾病 反复着床失败 卵细胞质量 精子质量 子宫内膜容受性 复方(中药) 综述 

分 类 号：R271.9[医药卫生—中西医结合]