紫杉醇在自体动静脉内瘘局部血管投递部位病理变化的研究  

Study on pathological changes of paclitaxel in local vascular delivery site of autogenous arteriovenous fistula

作　　者：周智勇 李莹 赵升艳 包洪靖 ZHOU Zhiyong;LI Ying;ZHAO Shengyan;BAO Hongjing(Department of Vascular Surgery,Xing'an Meng People's Hospital,Ulanhot 137400,China;Department of Ultrasound,Xing'an Meng People's Hospital)

机构地区：[1]兴安盟人民医院血管外科,内蒙古乌兰浩特137400 [2]兴安盟人民医院超声科

出　　处：《包头医学院学报》2023年第6期20-23,共4页Journal of Baotou Medical College

基　　金：2020年内蒙古自治区科技计划项目(2020GG0021)。

摘　　要：目的:探讨紫杉醇在自体动静脉内瘘局部血管投递的短期效果及可能机制。方法:将大耳白兔36只随机分为观察组和对照组,动物模型制作完成后在2周、4周、6周、8周、10周、12周分别手术取出动静脉内瘘血管,通过HE染色观察静脉血管组织形态学变化,通过免疫组化法观察静脉血管壁Beclin-1、LC3Ⅱ及PDGF-bb因子表达情况。结果:观察组静脉内膜厚度低于对照组(P<0.05),Beclin-1、LC3Ⅱ及PDGF-bb因子表达观察组略低于对照组,差异无统计学意义(P>0.05)。结论:自体动静脉内瘘局部血管投递紫杉醇可降低静脉内膜异常增生,为自体动静脉内瘘(AVF)狭窄提供了新的治疗思路。Objective:To investigate the short-term effect and possible mechanism of paclitaxel in local vascular delivery of autogenous arteriovenous fistula(AVF).Methods:Thirty-six white rabbits were randomly divided into observation group and control group.After the completion of the animal model,AVF vessels in each group were surgically removed at 2 weeks,4 weeks,6 weeks,8 weeks,10 weeks and 12 weeks,and the morphological changes of venous vessels were observed by HE staining.The expressions of Beclin-1,LC3Ⅱand PDGF-bb in venous wall were observed by immunohistochemistry.Results:The intima venous thickness in the observation group was lower than that in the control group(P<0.05),and the expression of Beclin-1,LC3Ⅱand PDGF-bb in the observation group was slightly lower than that in the control group,with no statistical significance(P>0.05).Conclusion:Local delivery of paclitaxel to autologous AVF can reduce the abnormal hyperplasia of the venous intima.It provides a new therapeutic idea for AVF stenosis.

关 键 词：自体动静脉内瘘 紫杉醇 投递 

分 类 号：R692.5[医药卫生—泌尿科学]