Zooming in and out of ferroptosis in human disease  

作　　者：Xue Wang Ye Zhou Junxia Min Fudi Wang 

机构地区：[1]The Second Affiliated Hospital,The First Affiliated Hospital,Institute of Translational Medicine,School of Public Health,State Key Laboratory of Experimental Hematology,Zhejiang University School of Medicine,Hangzhou 310058,China [2]The First Affiliated Hospital,Basic Medical Sciences,School of Public Health,Hengyang Medical School,University of South China,Hengyang 421001,China [3]Department of Endocrinology and Metabolism,Ningbo First Hospital,Ningbo 315000,China

出　　处：《Frontiers of Medicine》2023年第2期173-206,共34页医学前沿（英文版）

基　　金：support from the National Natural Science Foundation of China(No.31930057 to Fudi Wang and No.31970689 to Junxia Min);the National Key R&D Program(No.2018YFA0507801 to Junxia Min and No.2018YFA0507802 to Fudi Wang);the China Postdoctoral Science Foundation(No.2022M712733 to Xue Wang).

摘　　要：Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation.In the past decade,it has been implicated in the pathogenesis of various diseases that together involve almost every organ of the body,including various cancers,neurodegenerative diseases,cardiovascular diseases,lung diseases,liver diseases,kidney diseases,endocrine metabolic diseases,iron-overload-related diseases,orthopedic diseases and autoimmune diseases.Understanding the underlying molecular mechanisms of ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease conditions.Indeed,there are an expanding number of studies suggesting that ferroptosis serves as a bona-fide target for the prevention and treatment of these diseases in relevant pre-clinical models.In this review,we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human disease,while providing evidence in support of ferroptosis as a target for the treatment of these diseases.We also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease.

关 键 词：ferroptosis human disease iron metabolism lipid peroxidation ANTIOXIDATION 

分 类 号：R556[医药卫生—血液循环系统疾病]