中性粒细胞胞外陷阱在风湿免疫性疾病中的作用研究进展  

Research progress on the role of neutrophil extracellular traps in rheumatic immune disease

作　　者：王一茜 张少康 赵德安[1] WANG Yiqian;ZHANG Shaokang;ZHAO Dean(Department of Pediatrics,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China;Department of Neurology,the First People′s Hospital of Zhengzhou,Zhengzhou 450004,Henan Province,China)

机构地区：[1]新乡医学院第一附属医院儿科,河南卫辉453100 [2]郑州市第一人民医院神经内科,河南郑州450004

出　　处：《新乡医学院学报》2023年第7期696-700,共5页Journal of Xinxiang Medical University

摘　　要：中性粒细胞胞外陷阱(NETs)作为中性粒细胞所释放出的一种网状组织,在炎症反应中充当先天防御宿主的角色,能够诱导捕获并杀灭微生物;NETs可参与多种疾病的发生,具有双向免疫调节作用。NETs生成过剩或机体清除减少可导致系统性红斑狼疮、类风湿性关节炎、抗中性粒细胞胞质抗体相关性血管炎及川崎病等免疫性疾病。NETs可能成为风湿免疫性疾病诊断和治疗中新的靶点。Neutrophil extracellular traps(NETs)as a kind of network tissue released by neutrophil granulocytes,play a role of innate host defense in inflammatory response,and which can induce the capture and killing of microorganisms.NETs can participate in the occurrence of a variety of diseases and has bidirectional immunomodulatory effect.Excessive generation or reduced clearance of NETs in the body can lead to immune diseases such as systemic lupus erythematosus,rheumatoid arthritis,anti-neutrophil cytoplasmic antibody associated vasculitis,and Kawasaki disease.NETs may become a new target in the diagnosis and treatment of rheumatic immune diseases.

关 键 词：中性粒细胞胞外陷阱 中性粒细胞 风湿免疫性疾病 血管炎 

分 类 号：R593.2[医药卫生—内科学]