Comparative Genomics Reveals Evolutionary Drivers of Sessile Life and Left-right Shell Asymmetry in Bivalves  

作　　者：Yang Zhang Fan Mao Shu Xiao Haiyan Yu Zhiming Xiang Fei Xu Jun Li Lili Wang Yuanyan Xiong Mengqiu Chen Yongbo Bao Yuewen Deng Quan Huo Lvping Zhang Wenguang Liu Xuming Li Haitao Ma Yuehuan Zhang Xiyu Mu Min Liu Hongkun Zheng Nai-Kei Wong Ziniu Yu 

机构地区：[1]CAS Key Laboratory of Tropical Marine Bio-resources and Ecology and Guangdong Provincial Key Laboratory of Applied Marine Biology,Innovation Academy of South China Sea Ecology and Environmental Engineering,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China [2]Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou),Guangzhou 511458,China [3]Biomarker Technologies Co.,Ltd,Beijing 101301,China [4]CAS Key Laboratory of Experimental Marine Biology,Center for Mega-Science,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China [5]State Key Laboratory of Biocontrol,College of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China [6]Zhejiang Key Laboratory of Aquatic Germplasm Resources,College of Biological and Environmental Sciences,Zhejiang Wanli University,Ningbo 315100,China [7]College of Fisheries,Guangdong Ocean University,Zhanjiang 524088,China [8]Hebei Key Laboratory of Applied Chemistry,College of Environmental and Chemical Engineering,Yanshan University,Qinhuangdao 066044,China [9]Department of Pharmacology,Shantou University Medical College,Shantou 515041,China

出　　处：《Genomics, Proteomics & Bioinformatics》2022年第6期1078-1091,共14页基因组蛋白质组与生物信息学报（英文版）

基　　金：support from the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou),China(Grant No. GML2019ZD0407);the Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Science (Grant No. COMS2019Q11);the National Natural Science Foundation of China (Grant Nos. 32073002 and 31902404);the China Agricultural Research System (Grant No. CARS-49);the Science and Technology Program of Guangzhou, China (Grant No. 201804020073);Natural Science Foundation of Guangdong, China (Grant No. 2020A1515011533);the Program of the Pearl River Young Talents of Science and Technology in Guangzhou of China (Grant No. 201806010003);the Institution of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences (Grant Nos. ISEE2018PY01, ISEE2018PY03, and ISEE2018ZD01);the Science and Technology Planning Project of Guangdong Province, China (Grant Nos. 2017B030314052 and 201707010177)

摘　　要：Bivalves are species-rich mollusks with prominent protective roles in coastal ecosystems.Across these ancient lineages,colony-founding larvae anchor themselves either by byssus production or by cemented attachment.The latter mode of sessile life is strongly molded by left-right shell asymmetry during larval development of Ostreoida oysters such as Crassostrea hongkongensis.Here,we sequenced the genome of C.hongkongensis in high resolution and compared it to reference bivalve genomes to unveil genomic determinants driving cemented attachment and shell asymmetry.Importantly,loss of the homeobox gene Antennapedia(Antp)and broad expansion of lineagespecific extracellular gene families are implicated in a shift from byssal to cemented attachment in bivalves.Comparative transcriptomic analysis shows a conspicuous divergence between leftright asymmetrical C.hongkongensis and symmetrical Pinctada fucata in their expression profiles.Especially,a couple of orthologous transcription factor genes and lineage-specific shell-related gene families including that encoding tyrosinases are elevated,and may cooperatively govern asymmetrical shell formation in Ostreoida oysters.

关 键 词：Comparative genomics Ostreoida oyster ATTACHMENT Shell asymmetry BIVALVE 

分 类 号：Q953[生物学—动物学]