Recent advances in the efficient degradation of lignocellulosic metabolic networks by lytic polysaccharide monooxygenase  

作　　者：Xinran Yu Yue Zhao Junhong Yu Lushan Wang 

机构地区：[1]State Key Laboratory of Microbial Technology,Shandong University,Qingdao 266237,China [2]State Key Laboratory of Biological Fermentation Engineering of Beer,Qingdao 266035,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第4期529-539,共11页生物化学与生物物理学报（英文版）

基　　金：the grants from the Key Research and Development Program of Shandong Province(No.2021CXGC010803);Open Research Fund of State Key Laboratory of Biological Fermentation Engineering of Beer(No.2450021011).

摘　　要：Along with long-term evolution,the plant cell wall generates lignocellulose and other anti-degradation barriers to confront hydrolysis by fungi.Lytic polysaccharide monooxygenase(LPMO)is a newly defined oxidase in lignocellulosic degradation systems that significantly fuels hydrolysis.LPMO accepts electrons from wide sources,such as cellobiose dehydrogenase(CDH),glucose-methanol-choline(GMC)oxidoreductases,and small phenols.In addition,the extracellular cometabolic network formed by cosubstrates improves the degradation efficiency,forming a stable and efficient lignocellulose degradation system.In recent years,using structural proteomics to explore the internal structure and the complex redox system of LPMOs has become a research hotspot.In this review,the diversity of LPMOs,catalytic domains,carbohydrate binding modules,direct electron transfer with CDH,cosubstrates,and degradation networks of LPMOs are explored,which can provide a systematic reference for the application of lignocellulosic degradation systems in industrial approaches.

关 键 词：phylogenetic classification redox partner cosubstrate structural proteomics metabolic network 

分 类 号：O64[理学—物理化学]