汉族人群中ALDH2 rs671基因多态性与体脂含量的相关性  

Relationship between ALDH2 rs671 gene polymorphism and body fat content in Han population

作　　者：李绒[1] 李敏 马聪[1] Li Rong;Li Min;Ma Cong(Department of Health Medicine,the Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Department of Health Management,General Hospital of Xinjiang Military Region of the Chinese People′s Liberation Army,Urumqi 830000,China)

机构地区：[1]解放军总医院第二医学中心健康医学科、国家老年疾病临床医学研究中心,北京100853 [2]解放军新疆军区总医院健康管理科,乌鲁木齐830000

出　　处：《中华健康管理学杂志》2023年第6期444-448,共5页Chinese Journal of Health Management

基　　金：解放军总医院青年成长项目(QNC19045)。

摘　　要：目的探讨汉族人群中ALDH2 rs671基因多态性与体脂含量的相关性。方法本研究是横断面研究,选取2017年1月至2020年1月在解放军总医院第二医学中心健康医学科体检的汉族人共3943例(男2749例,女1194例);年龄(48.12±7.98)岁。研究对象按照体脂率水平分为肥胖组和非肥胖组。收集年龄、性别、疾病史、身高、体重、体脂含量等基本信息,采集血样本,进行ALDH2 rs671基因多态性检测。组间基因型及等位基因频率比较采用χ2检验,不同基因型间临床资料的比较用单因素方差分析。各指标及生活方式与基因型的相互关系采用logistic回归模型分析。结果ALDH2 rs671基因型的分布分别为野生型GG(68.6%),杂合突变型GL(28.7%),纯合突变型LL(2.7%),在肥胖组与非肥胖组的基线特征对比中男性占比(67.5%比71.3%)、体重指数[BMI,(23.12±2.64)比(27.10±2.75)kg/m^(2)]、基因型总体分布(GG 65.6%比70.6%)、饮酒史(64.4%比68.8%)、合并高血压(18.7%比36.9%)、冠心病(3.7%比5.6%)、糖尿病史(9.7%比15%)差异均有统计学意义(均P<0.05)。多因素logistic回归显示ALDH2-GG基因型(OR=1.386,95%CI:1.078~1.782)、年龄(OR=1.051,95%CI:1.035~1.068)、BMI(OR=2.182,95%CI:2.043~2.331)是体脂率肥胖的危险因素,性别中男性是保护因素(OR=0.175,95%CI:0.123~0.250)(均P<0.05)。结论ALDH2 rs671多态性与体脂含量相关,GG型基因个体具有较高的体脂含量超标风险。Objective To investigate the relationship between ALDH2 rs671 gene polymorphism and body fat content in Chinese Han population.Methods It was a cross-sectional study.A total of 3943 Chinese Han people were selected for physical examination in the Department of Health Medicine in the Second Medical Center of Chinese PLA General Hospital from January 2017 to January 2020,including 2749 males and 1194 females;the average age was(48.12±7.98)years.The research subjects were divided into obesity group and non-obesity group according to their body fat rate.The basic information including age,gender,disease history,height,weight,body fat content and blood samples were collected;the ALDH2 rs671 gene polymorphism was detected.Genotype and allele frequencies were compared between groups by using χ^(2)test.The comparison of clinical data between different genotypes was conducted by using one-way analysis of variance.The correlation between various indicators,lifestyle and genotype was analyzed by using a logistic regression model.Results The distribution of ALDH2 rs671 genotype was wild genotype GG(68.6%),heterozygous mutant genotype GL(28.7%)and homozygous mutant genotype LL(2.7%).In terms of baseline characteristics,there were significant differences in male(67.5%vs 71.3%),body mass index(BMI,(23.12±2.64)kg/m2 vs(27.10±2.75)kg/m2),genotype distribution(GG 65.6%vs 70.6%),drinking history(64.4%vs 68.8%),history of hypertension(18.7%vs 36.9%),coronary heart disease(3.7%vs 5.6%)and diabetes(9.7%vs 15.0%)between the obesity and non-obesity group(all P<0.05).Multifactor logistic regression showed that ALDH2-GG genotype(OR=1.386,95%CI:1.078-1.782),age(OR=1.051,95%CI:1.035-1.068),and BMI(OR=2.182,95%CI:2.043-2.331)were risk factors for obesity differentiated by body fat percentage,and male(OR=0.175,95%CI:0.123-0.250)was protective factor(all,P<0.05).Conclusion ALDH2 rs671 polymorphism is related to body fat content.The risk of excessive body fat content in individuals with GG genotype is significantly increased.

关 键 词：身体成分 肥胖 基因多态性 体脂含量 

分 类 号：R589.2[医药卫生—内分泌]