益生菌辅助治疗帕金森病的Meta分析  

Meta-analysis of probiotics in adjuvant treatment of Parkinson’s disease

作　　者：沈法 雷玉铃 张靖萍 范文辉 陈阳美[1] SHEN Fa;LEI Yuling;ZHANG Jingping;FAN Wenhui;CHEN Yangmei(Department of Neurology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing,400010;Department of Neurology,Chongqing Ninth People’s Hospital,Chongqing,400700;School of Nursing,Hangzhou Normal University,Hangzhou,Zhejiang Province,311121;Medical Research Institute,Southwest University,Chongqing,400700,China)

机构地区：[1]重庆医科大学附属第二医院神经内科,重庆400010 [2]重庆市第九人民医院神经内科,重庆400700 [3]杭州师范大学护理学院,杭州311121 [4]西南大学医学研究院,重庆400700

出　　处：《陆军军医大学学报》2023年第12期1369-1376,共8页Journal of Army Medical University

基　　金：北碚区基础研究与前沿探索项目(2020-24)。

摘　　要：目的评价益生菌辅助治疗帕金森病(Parkinson’s disease,PD)的临床疗效及不良反应。方法检索PubMed、Embase、Cochrane library、Web Of Science、Clinical Trials、中国知网(CNKI)、维普数据库(VIP)、万方数据库中关于益生菌辅助治疗帕金森病的随机对照研究(RCT),检索时间从建库至2022年6月30日,根据纳入排除标准筛选文献,使用Cochrane偏倚风险评估工具进行文献质量评价并提取资料,采用Review Manager 5.3软件进行Meta分析。结果最终纳入10项临床随机对照研究,共652例帕金森病患者。与对照组相比,试验组每周排便次数增高(SMD=1.30,95%CI:0.99~1.61,P<0.00001);试验组ADL、UPDRS-Ⅲ评分较安慰剂组差异不具有统计学意义(P>0.05)。结论服用益生菌产品能有效提升PD患者排便次数且不良反应少。Objective To systematically review the clinical efficacy and adverse reactions of probiotics in the adjuvant treatment of Parkinson’s disease(PD).MethodsPubMed,Embase,Cochrane Library,Web of Science,Clinical Trials,China Journal Full-text Database(CNKI)and VIP medical database were searched to collect randomized controlled trials(RCT)on the treatment of PD with probiotics up to June 30,2022.These studies were screened according to our inclusion and exclusion criteria,and the Cochrane bias risk assessment tool was used to evaluate the literature quality and extract the data,and Review Manager 5.3 software was used to conduct a meta-analysis.ResultsFinally,10 clinical randomized controlled studies with a total of 652 PD patients were included.Compared with the control group,the number of bowel movements per week increased in the experimental group(SMD=1.30,95%CI:0.99~1.61,P<0.00001).The difference between the experimental group and the placebo group was not statistically significant in activities of daily living(ADL)and Unified Parkinson’s Disease Rating Scale-Ⅲ(UPDRS-Ⅲ)scores.ConclusionProbiotic products can effectively improve the defecation frequency of PD patients,and result in less adverse reactions.

关 键 词：帕金森病 肠道菌群 益生菌 荟萃分析 

分 类 号：R442.2[医药卫生—诊断学] R459.9[医药卫生—临床医学] R742.5