调节因子X蛋白家族的结构与功能  

Structure and Function of The Regulatory Factor X Protein Family

作　　者：李红岩 尹秀 张祥敏 Li Hongyan;Yin Xiu;Zhang Xiangmin(Institute of Marine Biodiversity and Evolution,College of Marine Life,Ocean University of China,Qingdao 266003,China)

机构地区：[1]中国海洋大学海洋生命学院,海洋生物多样性与进化研究所,山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2023年第8期1-7,共7页Periodical of Ocean University of China

基　　金：国家重点研究发展计划项目(2018YFD0900502)资助。

摘　　要：调节因子X(Regulatory Factor X,RFX)蛋白家族是一类包含高度保守的有翼螺旋型DNA结合域的转录因子,因特异性结合基因启动子区的X盒而得名。该蛋白家族广泛分布于动物和真菌中,参与纤毛和精子发生、免疫反应以及细胞周期调控等多种生物过程。RFX家族的一些成员还对肿瘤细胞的存活及增殖起到促进或抑制作用,有望成为治疗肿瘤的新靶点。本文将对RFX蛋白家族的发现、各成员的结构特征、表达模式和生物学功能等进行综述,以期待为后续研究提供参考。Regulatory Factor X(RFX)protein family is a class of transcription factors which contain a highly conserved DNA binding domains of the winged-helix type.RFX proteins can specifically bind the X-box motifs of the gene promoter region.RFX protein family is widely distributed in animals and fungi and is involved in various biological processes such as occurrence of cilia and spermatogenesis,immune response,and cell cycle regulation.Some members of the RFX family also promote or inhibit the survival and proliferation of tumor cells,which is expected to be the new targets for tumor treatment.In this paper,we reviewed the discovery,structural characteristics,expression patterns and biological functions of the RFX protein family in order to provide references for subsequent studies.

关 键 词：转录因子 调节因子X家族 基因调控 生物学功能 肿瘤 

分 类 号：Q786[生物学—分子生物学]