蒙药土木香的化学成分研究  

Chemical constituents from Mongolian medicine Inulae Radix

作　　者：毛婷 毛乐 张屏[3] 高柏青 张勇[4] MAO Ting;MAO Le;ZHANG Ping;GAO Bai-qing;ZHANG Yong(The Third Affiliated Hospital of Inner Mongolia Medical University;The Third Affiliated Hospital of Baotou Medical College of Inner Mongolia Scientific and Technological University,Baotou 014040,China;Inner Mongolia Medical University,Hohhot 010110,China;The First Affiliated Hospital of Baotou Medical College of Inner Mongolia Scientific and Technological University,Baotou 014040,China)

机构地区：[1]内蒙古医科大学第三附属医院 [2]内蒙古科技大学包头医学院第三附属医院,包头014010 [3]内蒙古医科大学,呼和浩特010110 [4]内蒙古科技大学包头医学院第一附属医院,包头014010

出　　处：《天然产物研究与开发》2023年第6期973-980,共8页Natural Product Research and Development

基　　金：国家自然科学基金地区项目(81460651)。

摘　　要：研究蒙药土木香的化学成分,采用RP-HPLC、硝酸银硅胶色谱等方法分离纯化,应用NMR、MS等波谱技术鉴定化合物结构,共分离鉴定了22个单体化合物,分别为5α,6α-dihydroxy-eudesma-11(13)-dien-12,8β-olide(1)、4α-hydroxy-5-methoxy-5,8α-dimethyl-3-methylenedecahydronaphtho[2,3-b]furan-2-one(2)、木香烯内酯(3)、土木香内酯(4)、异土木香内酯(5)、11,13-二氢土木香内酯(6)、alloalantolactone(7)、4α,5β-环氧-1(10),11(13)-吉玛烷-12,8α-交酯(8)、septuplinolide(9)、8-epi-ivangustin(10)、santamarine(11)、racemosalactone A(12)、3-oxo-eudesma-4(11)-dien-12,8β-olide(13)、telekin(14)、igalane(15)、macrophyllilactone E(16)、4α,15-环氧异土木香内酯(17)、11,13-dihydroxy-alantolactone(18)、1(2),4(15),11(3)-eudesma-trien-12,8β-olide(19)、亚麻酸(20)、亚油酸(21)、油酸(22)。化合物1是新倍半萜内酯类化合物,化合物2、3、9~14、17、19~22为首次从该属植物中分离得到,化合物4~8、15、16、18为土木香药材中已报道的化合物。To study the chemical constituents from the roots of the Mongolian medicine Inulae Radix.The compounds were separated and purified by RP-HPLC and silver nitrate silica gel chromatography,and the structures of the compounds were identified by applying NMR and MS spectroscopy.Twenty-two monomeric compounds were isolated and identified as follows:5α,6α-dihydroxy-eudesma-11(13)-dien-12,8β-olide(1),4α-hydroxy-5-methoxy-5,8α-dimethyl-3-methylenedecahydronaphtho[2,3-b]furan-2-one(2),1(10),4(5),11(13)-germa-cradiene-8,12-olide(3),alantolactone(4),isoalantolactone(5),11,13-dihydro-5(6)-dine-alantolactone(6),alloalantolactone(7),4α,5β-epoxy-1(10),11(13)-germacra-dien-12,8α-olide(8),sseptuplinolide(9),8-epi-ivangustin(10),santamarine(11),racemosalactone A(12),3-oxo-eudesma-4(11)-dien-12,8β-olide(13),telekin(14),igalane(15),macrophyllilactone E(16),4α,15-epoxy-isoalantolactone(17),11,13-dihydroxy-alantolactone(18),1(2),4(15),11(3)-eudesma-trien-12,8β-olide(19),linolenic(20),linoleic acid(21),oleic acid(22).Compound 1 was a new sesquiterpenoes.Compounds 2,3,9-14,17,19-22 were isolated from genus Inula for the first time.Compounds 4-8,15,16,18 have been reported from Inulae Radix.

关 键 词：蒙药土木香 硝酸银硅胶柱色谱 化学成分 

分 类 号：R93[医药卫生—生药学]