橘皮素生物活性及其对运动性哮喘的潜在功效  

Biological activity of tangeretin and its potential efficacy in exercise-induced asthma:a review

作　　者：刘猛 章政 高炳宏[1] 周志钦[3,4] LIU Meng;ZHANG Zheng;GAO Bing-hong;ZHOU Zhi-qin(College of Physical Education and Training,Shanghai University of Sport,Shanghai 200438,China;Chongqing Institute of Sport Science,Chongqing 400010,China;Southwest University,Chongqing 400700,China;Southwest Institute of Fruits Nutrition,Chongqing 400054,China)

机构地区：[1]上海体育学院,上海200438 [2]重庆市体育科学研究所,重庆400010 [3]西南大学,重庆400700 [4]西南果品营养研究院,重庆400054

出　　处：《天然产物研究与开发》2023年第6期1088-1099,共12页Natural Product Research and Development

基　　金：冬季项目运动疲劳消除关键技术研究与应用(2019YFF0301603);上海市人类运动能力开发与保障重点实验室项目(17DZ2273100)。

摘　　要：运动性哮喘(exercise-induced asthma,EIA)作为运动员群体的第一大慢性疾病,正日益受到关注。虽然EIA的病理研究及药物治疗研究已取得一定进展,但长期服用EIA治疗药物不仅危害运动员身心健康,而且极易导致兴奋剂阳性问题。因此,亟需寻求一种安全、健康、有效的干预方法以替代药物治疗或降低药物依赖度。橘皮素是一种天然柑橘提取化合物,近年多项研究指出它在治疗EIA方面有巨大潜力。本文归纳、梳理与分析了橘皮素的多种生物活性,如:抗炎、抗氧化、抗肿瘤活性、调节尿酸与皮质醇合成分泌、调节糖脂代谢与抗肥胖、神经保护等,为深入研究和开发橘皮素食品、保健品及药品并用于EIA治疗提供思路与理论支撑。Exercise-induced asthma(EIA)is one of the most frequent chronic diseases among athletes and is gaining increasing concern.The pathological mechanisms and pharmacology-based treatments of EIA have been widely studied and some progress has been made,however,long-term using EIA drugs would induce health-related side effects and even doping violations.Thus,a safe,healthy and effective alternative of traditional treatment methods is particularly required.Tangeretin extracted from a natural citrus was recently reported to show great promise in EIA treatment.Therefore,the current article specifically reviewed the biological activities of tangeretin referring to anti-inflammatory,antioxidant,anti-cancer,regulation of uric acid and cortisol secretion,regulation of glucolipid metabolism and anti-obesity,neuroprotection.It would provide ideas and theoretical support for further studying and developing tangeretin-based food,healthcare products or drugs in EIA treatment.

关 键 词：橘皮素 运动性哮喘 生物活性 抗炎 抗氧化 

分 类 号：R932[医药卫生—生药学]