Genetic analysisofsuicide:asamplestudyinTuscany(CentralItaly)  

作　　者：Martina Focardi Barbara Gualco Vilma Pinchi Norelli Gian-Aristide Regina Rensi Elisabetta Pelo Ilaria Carboni Ugo Ricci 

机构地区：[1]Division of Genetic Diagnostics,University Hospital“Careggi”,Florence,Italy

出　　处：《Forensic Sciences Research》2022年第4期790-797,共8页法庭科学研究（英文）

摘　　要：Many studies have examined the genetic contribution to suicide.However,data on suicide in the Italian population are scarce.We therefore aimed to address this gap by investigating a cohort of 111 Italians for whom a verdict of suicide had been declared in court in Florence,Italy between 2007 and 2017.This cohort included 86 men and 25 women.DNA samples were obtained from tissues or blood,and 22 genes from multiple neurobiological pathways previously shown to be associated with the pathogenesis of suicide were analysed.Next-generation sequencing was used to compare these gene sequences with those from a large,normal population.In this study,we identified 19 gene variants that were present at significantly lower frequencies in our Italian cohort than in the general population.In addition,four missense mutations were identified in four different genes:Monoamine Oxidase A(MAOA),5-Hydroxytryptamine Receptor 2 A(HTR2A),Sodium Voltage-Gated Channel Alpha Subunit 8(SCN8A),and Nitric Oxide Synthase 3(NOS3).Our study identified several potential genetic links with suicide in a cohort of Italians and supports a relationship between specific genetic variants and suicidal behaviour in this population.

关 键 词：Forensic sciences forensic genetics SUICIDE MAOA HTR2A SCN8A NOS3 

分 类 号：S482.3[农业科学—农药学]