纳米乳作为眼部给药递送系统的研究进展  

Nanoemulsions as an Ophthalmic Drug Delivery System:Research Advances

作　　者：李方琴 闫巧 王芳 薛玉叶 杭凌宇 秦祉剑 袁海龙 LI Fang-qin;YAN Qiao;WANG Fang;XUE Yu-ye;HANG Ling-yu;QIN Zhi-jian;YUAN Hai-long(College of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Air Force Medical Center,PLA,Beijing 100142,China)

机构地区：[1]江西中医药大学药学院,江西南昌1330004 [2]空军特色医学中心,北京100142

出　　处：《解放军药学学报》2023年第3期270-276,共7页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金项目,No.81873092,82174074。

摘　　要：眼结构的复杂性和眼部屏障的存在会严重影响药物的吸收,导致生物利用度极低,这是眼部给药的一大难题,如何克服眼部给药递送难题是目前的研究热点。纳米乳能通过局部给药的方式渗透到眼后房,可以用于眼部给药,有望解决眼局部给药递送难题。本文综述了眼部屏障、纳米乳的制备和表征及其在眼部用药的应用研究,以期为眼部药物递送系统的研究提供参考与借鉴。A huge obstacle to ophthalmic delivery is the impact of the complex ophthalmic structure and ocular barriers on the absorption of drugs,resulting in extremely low bioavailability.Ways are being found to overcome the difficulty in ophthalmic delivery.Nanoemulsions can be delivered into the posterior chamber via local drug delivery,so they can be applied to ophthalmic delivery of drugs.In this paper,ocular barriers,preparation methods,characterization and research on applications of nanoemulsions are reviewed in order to provide reference for studies on low bioavailability of ophthalmic drug delivery systems.

关 键 词：纳米乳 眼部给药递送系统 生物利用度 眼部屏障 

分 类 号：R943[医药卫生—药剂学]