结核分枝杆菌毒力因子ESAT-6与巨噬细胞相互作用的研究进展  

Research progress on the interaction between Mycobacterium tuberculosis virulence factor ESAT-6 and Macrophages

作　　者：赵凤 周钰骐 徐铭晗 张林波[1] 韩鹏[1] ZHAO Feng;ZHOU Yuqi;XU Minghan;ZHANG Linbo;HAN Peng(College of Life Sciences,Jilin Agricultural University,Changchun 130118,China)

机构地区：[1]吉林农业大学生命科学学院,吉林长春130118

出　　处：《中国病原生物学杂志》2023年第6期742-744,F0003,共4页Journal of Pathogen Biology

基　　金：吉林省教育厅“十三五”科学技术项目(No.JJKH20180674KJ);吉林省大学生创新训练项目(No.S202210193069)。

摘　　要：ESAT-6是结核分枝杆菌分泌的重要的毒力因子之一,参与调控巨噬细胞凋亡、自噬、炎症激活等过程。在ESAT-6的研究中,多采用有载体协助入膜的重组ESAT-6质粒或ESAT-6基因敲除/增强菌株或从大肠埃希菌中表达获得的ESAT-6重组蛋白等不同形式。因此,本文对3种形式的重组ESAT-6与巨噬细胞的相互作用进行综述,探讨其对巨噬细胞的影响有何不同,以期为结核病的诊断和疫苗开发提供理论参考。ESAT-6,one of the major virulence secretions from Mycobacterium tuberculosis,gets involved in the regulation of macrophage apoptosis,autophagy,inflammation activation,and other processes.In existing studies on ESAT-6,the recombinant plasmid ESAT-6 with vector-assisted membrane entry,ESAT-6 knockout/enhanced strains,and ESAT-6 recombinant protein generated by Escherichia coli expression were discussed.Therefore,in this paper,the interaction between three forms of recombinant ESAT-6 and macrophages was reviewed to discuss how the three forms of recombinant ESAT-6 differ in their effects on macrophages,with the aim to provide theoretical references for the diagnosis and vaccine development of tuberculosis.

关 键 词：结核分枝杆菌 ESAT-6 巨噬细胞 作用机制 综述 

分 类 号：R378.99[医药卫生—病原生物学]