急性创伤后早期脑结构网络小世界属性的磁共振研究  

Small⁃world Characteristics in Brain Structural Network Shortly After Acute Stress:A MRI Study

作　　者：赵纳[1] 孟令惠[1] 张英东[2] 杜国帅 刘红冉 高明龙[2] 任贝贝 刘富荣 ZHAO Na;MENG Linghui;ZHANG Yingdong;DU Guoshuai;LIU Hongran;GAO Minglong;REN Beibei;LIU Furong(Department of CT/MRI,The Third Hospital of Hebei Medical University;Mental Health Center,The First Hospital of Hebei Medical University;Department of CT/MRI,Neiqiu Traditional Chinese Medicine Hospital)

机构地区：[1]河北医科大学第三医院CT/MRI室 [2]河北医科大学第一医院精神卫生中心 [3]河北省内丘县中医院CT/MRI室

出　　处：《中国医学计算机成像杂志》2023年第3期247-250,共4页Chinese Computed Medical Imaging

基　　金：河北省自然科学基金(H2020206278);河北省省级科技计划(20377734D)。

摘　　要：目的:采用基于磁共振弥散张量成像(DTI)的图论方法探讨急性创伤后早期脑结构网络拓扑属性,分析小世界属性的变化及其意义。方法:收集交通事故受害者31例作为创伤组,纳入同一时间段在社区招募的健康志愿者31名作为对照组,后者年龄、性别、受教育时间与创伤组相匹配。采集2组受试者临床数据和MRI数据,其中创伤组的数据采集在经历交通事故后1周内进行。采用所得DTI数据构建脑结构网络,比较2组脑结构网络属性的差异。结果:创伤组与对照组大脑结构网络均具有小世界属性。创伤组σ值、γ值较对照组升高,2组间差异具有统计学意义(P<0.05)。结论:急性创伤后早期脑结构网络具有小世界属性,其网络拓扑属性发生改变。Purpose:To investigate the topological organization of brain white matter networks shortly after acute stress and to analyze the features of the"small world"network using diffusion tensor imaging(DTI)with graph theory method.Methods:Thirty-one motor vehicle accident(MVA)survivors and thirty-one age-,gender-,and education degree-matched healthy controls were recruited.All subjects got MRI scan and clinical evaluation.MVA survivors received MRI scan and trauma-specific clinical assessments within 1 week from MVA.Topological properties of brain white matter networks were analyzed using DTI with graph theory method.Results:The brain white matter networks fitted the definition of small⁃worldness in MVA survivors and controls.Significantly higherσandγvalues were found in MVA survivors as compared with those in controls(P<0.05).Conclusion:These results indicate that the brain white matter networks of MVA survivors exhibit small-worldness,but altered topological properties shortly after acute stress.

关 键 词：急性应激 脑网络 小世界 弥散张量成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]