健脾消痞汤联合穴位贴敷治疗胃食管反流性咳嗽的疗效观察  

Clinical Observation on the Jianpi Xiaopi Decoction Combined with Acupoint Application in the Treatment of Gastroesophageal Reflux Cough

作　　者：周明萍[1] 卓进盛[1] 冯超[1] 吕佳杰[1] 王秀兰[1] 任永魁 ZHOU Ming-Ping;ZHUO Jin-Sheng;FENG Chao;LYU Jia-Jie;WANG Xiu-Lan;REN Yong-Kui(Dept.of Lung Disease,Hainan Hospital of Traditional Chinese Medicine,Haikou 570203 Hainan,China)

机构地区：[1]海南省中医院肺病科,海南海口570203

出　　处：《广州中医药大学学报》2023年第6期1376-1381,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：海南省卫生计生行业科研资助项目(编号:18A200090)。

摘　　要：【目的】观察健脾消痞汤联合穴位贴敷治疗胃食管反流性咳嗽的临床疗效。【方法】将90例患者随机分为观察组、中药组和西药组,每组各30例,观察组给予健脾消痞汤联合穴位贴敷治疗,中药组给予健脾消痞汤口服治疗,西药组给予奥美拉唑肠溶胶囊联合多潘立酮片口服治疗。连续治疗28 d。治疗4周后,评价2组临床疗效,观察2组患者治疗前后莱斯特咳嗽问卷(LCQ)评分的变化情况,以及反流性疾病问卷(RDQ)量表中反流症状指数(RSI)和反流体征(RFS)评分的变化情况。比较2组患者治疗前后24 h食管pH和阻抗监测指标的变化情况,并评价2组的安全性及不良反应的发生情况。【结果】(1)观察组总有效率为90.00%(27/30),中药组为83.33%(25/30),西药组为66.67%(20/30)。观察组疗效优于中药组与西药组,差异均有统计学意义(P<0.05)。(2)治疗后,3组患者的LCQ积分均明显改善(P<0.05),且观察组在改善LCQ积分方面明显优于两个对照组,差异均有统计学意义(P<0.05)。(3)治疗后,3组患者的RSI、RFS评分均明显改善(P<0.05),且观察组在改善RSI、RFS评分方面明显优于两个对照组,差异均有统计学意义(P<0.05)。(4)治疗后,3组患者的24 h食管pH监测指标均明显改善(P<0.05),且观察组在改善24 h食管pH监测指标方面明显优于两个对照组,差异均有统计学意义(P<0.05)。(5)3组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】健脾消痞汤联合穴位贴敷治疗胃食管反流性咳嗽,能明显改善患者的咳嗽和反流症状,疗效显著。Objective To investigate the clinical efficacy of Jianpi Xiaopi Decoction combined with acupoint application in the treatment of gastroesophageal reflux cough(GERC).Methods Ninety patients were randomly divided into the observation group,Chinese medicine group and western medicine group,with 30 patients in each group.The observation group was treated with Jianpi Xiaopi Decoction combined with acupoint application,the Chinese medicine group was treated with oral aministration of Jianpi Xiaopi Decoction,and the western medicine group was treated with oral use of Omeprazole Enteric-Coated Capsules combined with Domperidone Tablets.After 4 weeks of treatment,the clinical efficacy of the two groups was evaluated,and the changes in the Leicester Cough Questionnaire(LCQ)scores,as well as the changes in the reflux symptom index(RSI)and reflux fluid sign(RFS)scores on the reflux diagnostic questionnaire(RDQ)scale were observed in the two groups before and after treatment.The changes in the 24-hour pH and impedance monitoring indices of the oesophagus in the two groups were compared before and after treatment.The safety and the occurrence of adverse reactions in the two groups were evaluated.Results(1)The total effective rate was 90.00%(27/30)in the observation group,83.33%(25/30)in the Chinese medicine group and 66.67%(20/30)in the western medicine group.The efficacy of the observation group was superior to that of the Chinese medicine group and the western medicine group,and the differences were all statistically significant(P<0.05).(2)After treatment,the LCQ scores of patients in the three groups were significantly improved significantly(P<0.05),and the observation group was significantly superior to that of the control group in improving the LCQ scores,and the difference was statistically significant(P<0.05).(3)After treatment,the RSI and RFS scores of all three groups were significantly improved(P<0.05),and the observation group was significantly superior to that of the control group in improving the RSI and RFS score

关 键 词：健脾消痞汤 穴位贴敷 慢性咳嗽 胃食管反流性咳嗽 临床疗效 

分 类 号：R246.9[医药卫生—针灸推拿学]