雷火灸对Ⅱb型重症肌无力的治疗作用研究  

Therapeutic Effect of Thunder-Fire Moxibustion for the Treatment ofMyasthenia Gravis Type Ⅱb

作　　者：蔡冰星 苏逸宁 王欣贤 严玉英 邢月蒙 王珍妮 杨云英[1] CAI Bing-Xing;SU Yi-Ning;WANG Xin-Xian;YAN Yu-Ying;XING Yue-Meng;WANG Zhen-Ni;YANG Yun-Ying(The First Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510006

出　　处：《广州中医药大学学报》2023年第6期1443-1447,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广州市科学技术局基础研究计划基础与应用基础研究项目(编号:202102080136);广州中医药大学人文社科专项扶持项目(编号:2020SKXK10)。

摘　　要：【目的】观察雷火灸对Ⅱb型重症肌无力的治疗作用。【方法】将66例Ⅱb型重症肌无力患者随机分为对照组和试验组,每组各33例。对照组给予常规中西医结合治疗,试验组在对照组的基础上联合雷火灸治疗(取百会、合谷、足三里、三阴交等穴),疗程为1周。通过观察2组患者治疗前后重症肌无力复合量表(MGC)评分、生活质量重症肌无力特异性量表(MGQOL15)评分以及匹兹堡睡眠质量指数(PSQI)评分的变化情况,以评价2组患者的临床疗效,同时评价2组治疗方案的安全性。【结果】(1)研究过程中,试验组脱落2例,对照组脱落1例,最终共有63例患者完成临床试验。(2)治疗后,2组患者的MGC评分均较治疗前明显降低(P<0.05),且试验组的降低作用略优于对照组,组间治疗前后差值比较,差异有统计学意义(P<0.05),但治疗后组间比较,差异无统计学意义(P>0.05)。(3)治疗后,2组患者的MG-QOL15评分和PSQI评分均较治疗前明显降低(P<0.05),且试验组的降低作用均明显优于对照组,组间治疗后及治疗前后差值比较,差异均有统计学意义(P<0.05或P<0.01)。(4)治疗期间,2组患者均未发生明显不良反应,具有较高的安全性。【结论】雷火灸可提高Ⅱb型重症肌无力患者的生活质量,改善其睡眠质量;同时,对临床症状也有一定改善作用,但还需进一步临床验证。Objective To observe the therapeutic effect of thunder-fire moxibustion for the treatment of myasthenia gravis(MG)typeⅡb.Methods Sixty-six patients with MG typeⅡb were randomly divided into the control group and the trial group,with 33 cases in each group.The control group was given conventional integrated Chinese and western medicine treatment,while the trial group was treated with thunder-fire moxibustion on acupoints of Baihui(GV20),Hegu(LI4),Zusanli(ST36),Sanyinjiao(SP6)on the basis of treatment for the control group.The course of treatment for the two groups lasted one week.The changes in myasthenia gravis composite(MGC)scale scores,myasthenia gravis specific quality of life scale(MG-QOL15)scores and Pittsburgh Sleep Quality Index(PSQI)scores in the two groups were observed before and after treatment.And then the clinical efficacy and the safety of the treatment regimens in the two groups were evaluated.Results(1)During the trial,2 cases fell off from the trial group and one case fell off from the control group,and a total of 63 patients eventually completed the clinical trial.(2)After treatment,the MGC scores of patients in both groups were significantly decreased compared with those before treatment(P<0.05),and the decrease of MGC scores in the trial group was slightly superior to that of the control group.Statistically significant difference was presented in the pre-and post-treatment difference of MGC scores between the two groups(P<0.05),but there was no statistically significant difference in MGC scores after treatment between the two groups(P>0.05).(3)After treatment,the MG-QOL15 scores and PSQI scores of both groups were significantly decreased compared with those before treatment(P<0.05),and the decrease of the scores in the trial group was significantly superior to that of the control group.Statistically significant difference was presented in the pre-and post-treatment difference of MGC scores and in the MGC scores after treatment between the two groups(P<0.05 or P<0.01).(4)During the treatmen

关 键 词：重症肌无力 雷火灸 重症肌无力复合量表(MGC) 重症肌无力特异性量表(MG-QOL15) 匹兹堡睡眠质量指数(PSQI) 百会穴 合谷穴 足三里穴 

分 类 号：R246.1[医药卫生—针灸推拿学]