艾灸治疗子宫内膜异位症的Meta分析  

Meta-analysis of Moxibustion for the Treatment of Endometriosis

作　　者：贺芳姿 江钢辉[2] 陈沁怡 梁铭悦 HE Fang-Zi;JINAG Gang-Hui;CHEN Qin-Yi;LIANG Ming-Yue(School of Acupuncture,Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学针灸康复临床医学院,广东广州510006 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《广州中医药大学学报》2023年第6期1572-1580,共9页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】系统评价艾灸治疗子宫内膜异位症(EMs)的临床疗效和安全性。【方法】计算机检索中国知网期刊全文数据库(CNKI)、万方学术期刊全文数据库(Wanfang)、维普中文科技期刊数据库(VIP)、中国生物医学数据库(CBM)、美国生物医学信息检索系统(PubMed)、荷兰医学文摘(Embase)、国际循证医学图书馆(Cochrane Library)、科学网(web of science)等各大数据库。检索时间为各数据库自建库以来至2022年2月。查找以艾灸为主要方法治疗EMs的随机对照实验文献。采用Review Manager 5.3软件对数据进行Meta分析。采用Cochrane系统评价手册5.1.0的偏倚风险评估工具对纳入文献进行偏倚分析。【结果】共纳入11篇文献进行Meta分析,共827例患者。Meta分析结果显示:试验组较对照组有效率高[OR=4.63,95%CI(2.66,8.06),P<0.00001],痊愈率较对照组高[OR=1.99,95%CI(1.31,3.01),P=0.001],CA125水平低于对照组[SMD=-0.57,95%CI(-1.08,-0.06),P=0.03],VAS评分低于对照组[MD=-1.42,95%CI(-2.26,-0.59),P=0.0009],白细胞介素水平低于对照组[MD=-9.06,95%CI(-13.94,-4.18),P=0.0003],盆腔包块体积小于对照组[MD=-1.36,95%CI(-1.60,-1.12),P<0.00001]。【结论】艾灸治疗子宫内膜异位症较对照组具有更好的临床效果,但由于纳入文献数量少且质量不高,未来仍需开展高质量的随机对照试验以深入验证这一结论。Objective To systematically evaluate the clinical efficacy and safety of moxibustion for the treatment of endometriosis(EMs).Methods Computer searches of major databases such as CNKI,Wanfang,VIP,CBM,PubMed,Embase,Cochrane Library,Web of Science and other major databases.The retrieval time was from the inception of each database to February 2022.The literature of randomized controlled trials using moxibustion as the main method of treating EMs was searched.Meta-analysis of the data was performed using Review Manager 5.3 software.The risk of bias assessment tool of the Cochrane systematic appraisal manual 5.1.0 was used to conduct bias analysis of the included literature.Results A total of 11 literatures were included for Meta-analysis,involving a total of 827 patients.Meta-analysis results showed that the trial group had higher effective rate[OR=4.63,95%CI(2.66,8.06),P<0.00001]and higher recovery rate[OR=1.99,95%CI(1.31,3.01),P=0.001]than the control group.CA125 levels[SMD=-0.57,95%CI(-1.08,-0.06),P=0.03],VAS scores[MD=-1.42,95%CI(-2.26,-0.59),P=0.0009]and interleukin levels[MD=-9.06,95%CI(-13.94,-4.18),P=0.0003]were lower than those in the control group,and pelvic mass volume[MD=-1.36,95%CI(-1.60,-1.12),P<0.00001]was smaller than that in the control group.Conclusion Moxibustion in the treatment of endometriosis had better clinical efficacy than the control group.However,due to the small number and low quality of included literature,future high-quality randomized controlled trials are still needed in the future to further verify this conclusion.

关 键 词：艾灸疗法 子宫内膜异位症 随机对照试验 META分析 

分 类 号：R246.9[医药卫生—针灸推拿学]