上海市结核病相关医务工作者结核潜伏感染及危险因素研究  

Latent tuberculosis infection status and its risk factors among tuberculosis-related health-care workers in Shanghai

作　　者：饶立歆 沙巍[2] 龚惠莉 唐利红[4] 路丽苹[5] 刘艳[6] 吴哲渊[1] 张祖荣[1] 沈鑫[1] 姜庆五[7] RAO Lixin;SHA Wei;GONG Huili;TANG Lihong;LU Liping;LIU Yan;WU Zheyuan;ZHANG Zurong;SHEN Xin;JIANG Qingwu(Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Shanghai Pulmonary Hospital,Shanghai 200433,China;Shanghai Pudong Pulmonary Hospital,Shanghai 200135,China;Shanghai Minhang District Center for Disease Control and Prevention,Shanghai 201101,China;Shanghai Songjiang District Center for Disease Control and Prevention,Shanghai 201620,China;Shanghai Putuo District Center for Disease Control and Prevention,Shanghai 200333,China;School of Public Health,Fudan University,Shanghai 200032,China)

机构地区：[1]上海市疾病预防控制中心,上海200336 [2]上海市肺科医院,上海200433 [3]上海市浦东新区肺科医院,上海200135 [4]上海市闵行区疾病预防控制中心,上海201101 [5]上海市松江区疾病预防控制中心,上海201620 [6]上海市普陀区疾病预防控制中心,上海200333 [7]复旦大学公共卫生学院,上海200032

出　　处：《上海预防医学》2023年第3期203-207,共5页Shanghai Journal of Preventive Medicine

基　　金：国家自然科学基金(81872679);上海市公共卫生体系建设三年行动计划(2020—2022年)优秀学科带头人(GWV-10.2-XD23);上海市卫生健康委员会青年项目(20204Y0212)。

摘　　要：【目的】了解上海市结核病相关医务人员的结核感染现况,并探寻与结核潜伏感染相关的危险因素。【方法】采用多中心横断面研究,选取上海市多家结核病定点医院、疾病预防控制中心、社区卫生服务中心的医务工作者,对其进行问卷调查和结核感染检测。运用单因素和多因素分析探究与结核感染有关的危险因素。【结果】纳入结核相关医务人员165例,结核感染率为16.36%(95%CI:11.49%~22.76%)。多因素logistic回归分析显示临床医护(调整OR=9.756,95%CI:1.790~53.188)、实验室检测(调整OR=78.975,95%CI:8.749~712.918)和护工(含保洁)人员(调整OR=89.920,95%CI:3.111~2 598.930)的结核感染风险更高。【结论】上海结核病相关医务工作者结核感染率低于全国水平,结核病定点医院从事临床医护、实验室检测和护工(含保洁)的医务人员结核感染风险显著高于在其他机构工作的医务人员。[Objective]To obtain the status of latent tuberculosis infection(LTBI)among tuberculosis(TB)-related health-care workers(HCWs)in Shanghai,and to explore the risk factors related to TB infection.[Methods]A multi-center cross-sectional study was conducted by recruiting medical workers from multiple designated TB hospitals,centers for disease control and prevention,and community health service centers in Shanghai.Each subject was required to complete a questionnaire and to provide a blood sample for TB infection test.Univariate and multivariate analysis ware made in order to find risk factors relating to TB infection.[Results]A total of 165 medical workers were recruited,and the proportion of TB infection was 16.36%(95%CI:11.49%‒22.76%).Multivariate logistic analysis showed that clinical doctors and nurses(adjusted OR=9.756,95%CI:1.790‒53.188),laboratory staffs(adjusted OR=78.975,95%CI:8.749‒712.918),and nursing and cleaning workers(adjusted OR=89.920,95%CI:3.111‒2598.930)had higher risk of TB infection.[Conclusion]The overall LTBI prevalence among TB-related HCWs is low.However,working as doctors,nurses,laboratory staffs,nursing workers and cleaning workers are risk factors of TB infection.TB-related HCWs who work at hospitals are at risk of TB infection comparing to medical staffs who work outside hospitals.

关 键 词：结核潜伏感染 结核相关医务工作者 结核感染筛查 

分 类 号：R183[医药卫生—流行病学]