精子形态学异常的遗传学研究进展  

Advances in the genetic researches of human sperm morphological abnormality and teratozoospermia

作　　者：董凡 陈向锋[1] Dong Fan;Chen Xiangfeng(Center for Reproductive Medicine,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200135,China)

机构地区：[1]上海交通大学医学院附属仁济医院生殖医学中心,上海200135

出　　处：《中华生殖与避孕杂志》2023年第5期461-467,共7页Chinese Journal of Reproduction and Contraception

摘　　要：精子形态学异常和畸形精子症是男性不育的重要原因之一。近年来随着研究的深入,遗传学因素被发现是导致精子形态学异常和畸形精子症的重要病因。本文就近年来精子形态学异常和畸形精子症的遗传学研究进展作一综述,从畸形精子症诊断、基因异常、染色体异常、生殖结局等角度阐释遗传因素与畸形精子症的关系,重点阐述了特殊类型畸形精子症,如圆头精子症、鞭毛多发形态异常等表型相关的基因异常。本文旨在为精子形态学异常及畸形精子症的诊疗和研究提供遗传学角度新的思路。Morphological abnormality of human sperm and teratozoospermia is one of the key causes of male infertility.With the progress of recent researches,more genetic causes were found to be involved in the pathogenesis of sperm morphological abnormality and teratozoospermia.This review analyzed the advances in genetic researches of human sperm morphological abnormality and teratozoospermia.We summarized the diagnosis of teratozoospermia,teratozoospermia-related genes,chromosomal abnormalities-related teratozoospermia as well as the reproductive outcomes of teratozoospermia.We also emphasized the relationship between genetic abnormalities and some special types of teratozoospermia,such as globozoospermia and multiple morphological abnormalities of the flagella(MMAF).We hope the article could give new genetic insight into the diagnosis,treatment and study of human sperm morphological abnormality and teratozoospermia.

关 键 词：不育 男性 畸形精子症 遗传 基因 染色体 精子形态 

分 类 号：R698.2[医药卫生—泌尿科学]