红花绿绒蒿的化学成分研究  

Study on chemical constituents of Meconopsis punicea

作　　者：黄银 刘雁勇 阿呷尔布[1,2] 谢红军[1] 熊海[1] 叶本贵 HUANG Yin;LIU Yanyong;AGA Erbu;XIE Hongjun;XIONG Hai;YE Bengui(Medical College of Tibet University,Lasa,Tibet,850002 P.R.China;West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China)

机构地区：[1]西藏大学医学院,西藏拉萨850002 [2]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2023年第3期246-250,共5页West China Journal of Pharmaceutical Sciences

基　　金：西藏教育厅重大委托项目(2020QT022);西藏科技厅科技重大专项(ZDZX2021000109,XZ202101ZD0021G);西藏科技厅2023年科技计划项目(XZ202301ZY);西藏科技厅2023年中央引导地方科技成果转移转化项目(XZ202301YD0014C,0009G)。

摘　　要：目的研究红花绿绒蒿全草中的化学成分。方法采用正相硅胶柱层析、反相制备色谱分离纯化红花绿绒蒿80%乙醇提取物中的化学成分,并通过薄层色谱、质谱、核磁共振数据测定其结构。结果从红花绿绒蒿乙醇提取物中分离得到13个化合物,分别鉴定为heptadecan-8-ol(Ⅰ)、二十三烷醇(Ⅱ)、tridecyl docosanoate(Ⅲ)、间羟基苯甲酸(Ⅳ)、β-谷甾醇(Ⅴ)、小麦黄素(Ⅵ)、大风子素(Ⅶ)、木犀草素(Ⅷ)、小檗碱(Ⅸ)、阿苞碱(Ⅹ)、血根碱(Ⅺ)、普托品碱(Ⅻ)、N-反式对羟基肉桂酰基-对羟基苯乙胺(ⅩⅢ)。结论化合物Ⅰ~Ⅳ为首次从绿绒蒿属植物中分离得到。OBJECTIVE To study the constituents of the plant Meconopsis punicea Maxim.Fl.Tangut.METHODS Reversed-phase preparative liquid chromatography and normal-phase silica gel column chromatography methods were used for the isolation and the purification of compounds from the soluble of 80%ethanol extracts from M.punicea.Their structures were elucidated by TLC,MS and NMR data.RESULTS Thirteen compounds were isolated from ethanol extract of M.punicea identified as heptadecan-8-ol(Ⅰ),1-tricosanol(Ⅱ),tridecyl docosanoate(Ⅲ),m-hydroxybenzoic acid(Ⅳ),β-sitosterol(Ⅴ),tricin(Ⅵ),hydnocarpin(Ⅶ),luteolin(Ⅷ),berberine(Ⅸ),alborine(Ⅹ),sanguinarin(Ⅺ),protopine(Ⅻ),trans-N-p-coumaroyl tyramine(ⅩⅢ).CONCLUSION CompoundsⅠ-Ⅳ have been isolated from this genus for the first time.

关 键 词：罂粟科 绿绒蒿属 红花绿绒蒿 化学成分 反向制备色谱 结构鉴定 黄酮 生物碱 

分 类 号：R28[医药卫生—中药学]