血液衰老:定义与范畴  

Blood aging:definition and scope

作　　者：靳凤艳[1] 薛华[2] 孙亮[3] 兰茂卓 张凌怡 张江勃[2] 田梦茹 李玉军 黎健 戴云[4] 中国老年学和老年病学学会老年病学分会血液学专家委员会 JIN FengYan;XUE Hua;SUN Liang;LAN MaoZhuo;ZHANG LingYi;ZHANG JiangBo;TIAN MengRu;LI YuJun;LI Jian;DAI Yun;Committee of Experts on Hematology(China Society of Geriatrics,China Association of Gerontology and Geriatrics)(Department of Hematology,First Hospital of Jilin University,Changchun 130012,China;Department of Hematology,Afiliated Hospital of Hebei University,Baoding 071030,China;The Key Laboratory of Geriatrics,Bejing Institute of Geriatrics,Beijing Hospital,National Center of Gerontology,National Health Commission,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100005,China;Laboratory of Cancer Precision Medicine,First Hospital of Jilin University,Changchun 130061,China;Second Hospital of Jilin University,Changchun 130041,China;不详)

机构地区：[1]吉林大学白求恩第一医院血液科,长春130012 [2]河北大学附属医院血液科,保定071030 [3]北京医院国家卫生健康委北京老年医学研究所,北京100005 [4]吉林大学白求恩第一医院肿瘤精准医学实验室,长春130061 [5]吉林大学第二医院,长春130041 [6]不详

出　　处：《中国科学：生命科学》2023年第6期789-807,共19页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:81471165,81670190,81670189,81870160,81971108);吉林省自然科学基金学科布局项目(批准号:20190201042JC,20190201163JC);吉林省中青年科技创新创业卓越人才(团队)项目(创新类)(批准号:20210509010RQ);吉林大学“学科交叉融合创新”项目(2021)资助。

摘　　要：一般认为,血液老化是人体衰老的根源.血液系统随年龄增长而发生生理性或病理性变化,导致造血干/祖细胞(HSC/HPC)衰老、免疫衰老、炎性衰老等,驱动或参与机体和几乎所有系统/器官的衰老,并引起多种老年性血液系统疾病(特别是恶性肿瘤).虽然“血液衰老(blood aging)”这一名词已在许多论文和日常生活中提及,但尚无确切的定义,其涵盖的领域也不清楚.实际上,随着衰老(包括整体、系统/器官、细胞乃至分子的衰老)研究的迅速拓展和深入,血液衰老的多个方面(如HSC/HPC衰老、免疫衰老、炎性衰老等)已广泛渗透到几乎所有的衰老研究领域,但其本身却迄今未形成一个领域,与迅速发展的临床老年血液学形成了鲜明的反差.因此,本文尝试对血液衰老进行定义(包括生理性和病理性血液衰老),并概要综述了其可能涵盖的范畴(生理性衰老包括HSC/HPC衰老、不同类型血细胞衰老及血液的衰老生物标志物;病理性衰老包括红系、髓系、淋系、巨核细胞/血小板的老年性良性疾病或恶性肿瘤,以及老年患者的衰弱及其评估),供学者们讨论.Aged blood is often considered a source of aging.Numerous physiological and pathological changes occur with increasing age,resulting in dysfunction of hematopoietic stem cells(HSCs)or progenitor cells(HPCs),immune senescence(or immunoaging),and inflammation.These age-related changes either drive or contribute to the aging of the organism and various systems and organs,as well as cause many age-associated hematological diseases(particularly hematologic malignancies)in the elderly.However,although the term"blood aging"has been used in a number of studies and in daily life,its definition and scope remain unclear.Several aspects of blood aging(e.g.,HSC/HPC aging,immune senescence,and inflammation)have been widely implicated in virtually all fields in the aging area,except defining blood aging itself as a field of aging research.This is in sharp contrast to the burgeoning field of clinical geriatric hematology.In this review article,we attempt to define blood aging and outline its scope to facilitate future research and clinical practice involving this emerging field.Based on the general definition of aging,blood aging can be defined as a progressive decline or loss of physiological functions of the hematopoietic system and blood(particularly various blood cells)with age(particularly various blood cells)and a decline in adaptability to environmental stresses,leading to an increase in the susceptibility to hematological diseases(this definition is open for discussion).The scope of blood aging covers both physiological aging(defined as the gradual age-related deterioration of hematopoiesis and blood cell functions,including aging of HSCs/HPCs and various blood cell types,and aging biomarkers in the blood)and pathological aging(defined as age-related or aging-associated pathogenesis of various hematological diseases,e.g.,clonal hematopoiesis,erythroid disorders such as anemia,myeloid or lymphoid malignancies,hyperactivity of the megakaryocyte/platelet axis,frailty,among others).

关 键 词：血液衰老 定义 范畴 生理性衰老 病理性衰老 

分 类 号：R339.38[医药卫生—人体生理学]