慢性萎缩性胃炎发病机制的研究进展  

Advances in the pathogenesis of chronic atrophic gastritis

作　　者：付阳茜 韩旭 梁硕 林芳冰(审校)[1] FU Yangxi;HAN Xu;LIANG Shuo;LIN Fangbing(Department of Gastroenterology,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing,100700,China)

机构地区：[1]北京中医药大学东直门医院消化科,北京100700

出　　处：《中国中西医结合消化杂志》2023年第6期479-484,共6页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家重点研发计划项目(No:2018YFC1704100,No:2018YFC1704101)。

摘　　要：慢性萎缩性胃炎属于胃癌的癌前疾病状态,是炎-癌转化的发生关口,近年来患病率呈上升且有年轻化趋势,严重威胁人类生活健康。目前慢性萎缩性胃炎的发病机制尚未明确统一,研究发现慢性萎缩性胃炎发病与幽门螺杆菌感染、自身免疫反应异常、胆汁反流和胃内非幽门螺杆菌菌群等相关。笔者查阅国内外相关文献资料,整理慢性萎缩性胃炎的相关发病机制,以供学习交流。Chronic atrophic gastritis is a precancerous disease state of gastric cancer,which is the key to the occurrence of inflammatory-cancer transformation.In recent years,the prevalence rate is on the rise and tends to be younger,which seriously threatens human life and health.At present,the pathogenesis of chronic atrophic gastritis has not been clearly unified.Studies have found that the pathogenesis of chronic atrophic gastritis is related to helicobacter pylori infection,abnoral autoimmune reaction,bile reflux and non-helicobacter pylori flora in the stomach.The author consulted relevant literature at home and abroad to sort out the pathogenesis of chronic atrophic gastritis for learning and communication.

关 键 词：慢性萎缩性胃炎 发病机制 幽门螺杆菌 自身免疫反应异常 胆汁反流 胃内非幽门螺杆菌菌群 

分 类 号：R256[医药卫生—中医内科学]