益气活血化瘀汤治疗冠心病气虚血瘀证临床研究  

Clinical Study on Decoction for Boosting Qi and Activating Blood and Removing Stasis in Treating Coronary Heart Disease with Qi Deficiency and Blood Stasis Syndrome

作　　者：徐舒蔓 李飞兵 郑钰坤 XU Shuman;LI Feibing;ZHENG Yukun(Jingdezhen Hospital of Traditional Chinese Medicine,Jingdezhen,Jiangxi,China,333000)

机构地区：[1]景德镇市中医医院,江西景德镇333000

出　　处：《河南中医》2023年第7期1056-1061,共6页Henan Traditional Chinese Medicine

基　　金：江西省中医药管理局科技计划项目(2019B219)。

摘　　要：目的:观察益气活血化瘀汤对冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CHD)气虚血瘀证患者血清超氧化物歧化酶(superoxide dismutase,SOD)、血脂水平以及血小板相关参数的影响。方法:将100例CHD气虚血瘀证患者按照随机数字表法分为对照组和观察组,每组各50例。对照组给予常规西药治疗,观察组在对照组治疗的基础上加用益气活血化瘀汤。比较两组患者的临床疗效及治疗前后中医证候积分、心绞痛发作情况、SOD、血脂水平[三酰甘油(triacylglycerol,TG)、血清总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白(high density lipoprotein cholesterol,HDL-C)]、血小板各参数[血小板压积(platelet crit,PCT)、大血小板比率(platelet-large cell ratio,P-LCR)、血小板体积分布宽度(platelet distribution width,PDW)、平均血小板体积(mean platelet volume,MPV)]、心功能[左心室射血分数(left ventricular ejection fraction,LVEF)、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、每搏输出量(stroke volume,SV)]及西雅图心绞痛调查量表(seattle angina questionaire,SAQ)评分变化情况。结果:观察组有效率为92.00%,对照组有效率为76.00%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后各项中医证候积分、心绞痛每周发作频率、每次持续时间、硝酸甘油每日消耗量、PCT、P-LCR、PDW及MPV低于本组治疗前,且治疗后观察组低于对照组(P<0.05)。两组患者治疗后SAQ各维度评分及SOD水平高于本组治疗前,且治疗后观察组高于对照组(P<0.05)。两组患者治疗后HDL-C、LVEF、SV高于本组治疗前,TC、TG、LDL-C、LVEDD均低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。结论:益气活血化瘀汤治疗CHD气虚血瘀证,可显著缓解患者心绞痛症状,调节SOD及血脂水平,改善血小板参数Objective:To observe the influence of Decoction for Boosting Qi and Activating Blood and Removing Stasis on serum superoxide dismutase(SOD),blood lipid level and platelet-related parameters in patients with coronary atherosclerotic heart disease(CHD)with qi deficiency and blood stasis syndrome.Methods:A total of 100 CHD patients with qi deficiency and blood stasis syndrome were randomly divided into the control group and the observation group,with 50 cases in each group.The control group received conventional Western medicine treatment,while the observation group received Decoction for Boosting Qi and Activating Blood and Removing Stasis on the basis of the control group.Then the clinical efficacy,and the changes in the scores of TCM syndromes,angina attacks,SOD,blood lipid levels[including triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],platelet parameters[including platelet crit(PCT),platelet large cell ratio(P-LCR),platelet distribution width(PDW),mean platelet volume(MPV)J,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),stroke volume(SV)] and Seatle angina questionnaire(SAQ)scores of the two groups before and after treatment were compared.Results:The effective rate of the observation group was 92.00%,while that of the control group was 76.00%.The difference between the two groups was statistically significant(P<0.05).Affer treatment,the scores of various TCM syndromes,frequency and duration of angina pectoris,daily consumption of nitroglycerin,PCT,P-LCR,PDW,and MPV of the two groups were lower than those before treatment,and the observation group's above indexes were lower than those of the control group(P<0.05);The SAQ scores and SOD levels of both groups were higher than those before treatment,and the observation group's above indexes were higher than those of the control group(P<0.05);The HDL-C,LVEF,and SV of the two groups were higher than those before treatmen

关 键 词：冠状动脉粥样硬化性心脏病 气虚血瘀证 益气活血化瘀汤 中西医结合疗法 

分 类 号：R259.414[医药卫生—中西医结合]