血必净联合微量泵持续泵入胰岛素对糖尿病酮症酸中毒患者的影响  

Effect of Xuebijing Combined with Micropump Continuously Pumping Insulin on Diabetic Ketoacidosis Patients

作　　者：黄艳 HUANG Yan(Fenyang College of Shanxi Medical University,Fenyang 032200,China)

机构地区：[1]山西医科大学汾阳学院,山西汾阳032200

出　　处：《中外医学研究》2023年第16期29-33,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究血必净联合微量泵持续泵入胰岛素对糖尿病酮症酸中毒患者的影响。方法:选择2021年1月—2022年1月山西省汾阳医院收治的84例糖尿病酮症酸中毒患者为研究对象,采用掷硬币法分为对照组和观察组,各42例。对照组进行微量泵持续泵入胰岛素治疗,观察组在对照组基础上联合血必净药物治疗。比较两组的治疗效果、氧化应激指标、炎症因子、不良反应及疗效满意度。结果:治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组氧化应激指标比较,差异无统计学意义(P>0.05);治疗后,观察组丙二醛(MDA)水平低于对照组,超氧化物歧化酶(SOD)、总抗氧化能力(TAC)水平高于对照组,差异有统计学意义(P<0.05)。治疗前,两组炎症因子水平比较,差异无统计学意义(P>0.05),治疗后,观察组肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。观察组疗效满意度高于对照组,差异有统计学意义(P<0.05)。结论:血必净联合微量泵持续泵入胰岛素能够有效降低糖尿病酮症酸中毒患者的炎症因子水平,缓解患者的氧化应激损伤,且疗效安全可靠,有助于提高患者的满意度。Objective:To explore the effect of Xuebijing combined with micropump continuously pumping insulin on patients with diabetes ketoacidosis.Method:A total of 84 patients with diabetes ketoacidosis admitted to Shanxi Fenyang Hospital from January 2021 to January 2022 were selected as the study objects,and they were divided into control group and observation group by coin toss,with 42 patients in each group.The control group received continuous infusion of insulin with a micropump,while the observation group received combined treatment with Xuebijing on the basis of the control group.The treatment efficacy,oxidative stress indicators,inflammatory factors,adverse reactions,and satisfaction with the efficacy between the two groups were compared.Result:After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in oxidative stress indicators between the two groups(P>0.05).After treatment,the level of malondialdehyde(MDA)in the observation group was lower than that in the control group,while superoxide dismutase(SOD)and total antioxidant capacity(TAC)were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the levels of inflammatory factors between the two groups(P>0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The satisfaction with the therapeutic effect of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Xuebijing combined with micropump continuously pumping i

关 键 词：糖尿病酮症酸中毒 血必净 有效率 氧化应激 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]