基于中西医临床病证特点的冠心病心绞痛动物模型分析  

Animal Models of Coronary Heart Disease Angina Pectoris:An Analysis Based on Clinical Characteristics of Traditional Chinese and Western Medicine

作　　者：徐舒婷 方晓艳[1] 王萍 苗明三[1] XU Shuting;FANG Xiaoyan;WANG Ping;MIAO Mingsan(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学药学院,郑州450046

出　　处：《中药药理与临床》2023年第4期92-96,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局标准化项目(编号:GZY-FJS-2020-219);河南省重大公益专项(编号:201300310100);河南省药品监督管理局科技计划项目(编号:2020DB034-49)。

摘　　要：冠心病(Coronary heart disease, CHD)发病率逐年升高,严重危害患者的生活质量。基于冠心病心绞痛的中西医临床病证特点,对目前现有的冠心病心绞痛动物模型进行归纳,分析冠心病心绞痛各个动物模型的优缺点、中西医诊断标准和临床吻合度,对相应动物模型进行评价。总结发现多数动物模型与中医临床吻合度较低,难以反映不同证型的病理特点。临床上多以西医诊断标准作为指导原则,与中医的整体观念有一定差距,因此本研究的开展,可为复制出更符合中西医临床病证特点的冠心病心绞痛动物模型提供思路,进而深入地研究临床药物筛选和防治方法。The incidence of coronary heart disease(CHD)has been increasing year after year,seriously affecting the quality of life of patients.Based on the clinical characteristics of CHD angina pectoris in traditional Chinese and western medicine,this paper summarized the existing animal models of CHD angina pectoris and analyzed their respective advantages and disadvantages as well as clinical consistency with the diagnostic criteria in traditional Chinese and western medicine.It was found that most animal models exhibited low consistency with the clinical features of traditional Chinese medicine,so they were not likely to reflect the pathological characteristics of different syndromes.The clinical diagnosis standard of western medicine is often used as the guiding principle,which is different from the concept of holism in traditional Chinese medicine.Therefore,such exploration will provide new ideas for replicating the CHD angina pectoris animal model more in line with the clinical characteristics of traditional Chinese and western medicine,thus facilitating clinical drug screening and in-depth study of prevention and control methods.

关 键 词：胸痹 临床病证 心绞痛 动物模型 

分 类 号：R541.4[医药卫生—心血管疾病] R-332[医药卫生—内科学]