孟河医派费氏治疗痹证用药规律研究  

The Fei’s Medication Rules against Bizheng(痹证)in Menghe(孟河)Medical School

作　　者：常俊杰 刘亦冰 戴文昊 解强 高俊[1,2] 张曦 CHANG Junjie;LIU Yibing;DAI Wenhao;XIE Qiang;GAO Jun;ZHANG Xi(Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine,Changzhou 213003;Zhang Xi's Famous Traditional Chinese Medicine Studio,Changzhou 213003)

机构地区：[1]南京中医药大学常州附属医院,常州213003 [2]张曦名中医工作室,常州213003

出　　处：《中药药理与临床》2023年第4期102-106,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：江苏省级重点研发计划(社会发展)项目(编号:BE2019653);江苏省研究生实践创新计划(编号:SJCX21_0804)。

摘　　要：目的:基于IBM SPSS系列统计软件,探索孟河医派费氏代表性人物治疗痹证的组方用药规律和特色。方法:收集孟河医派费伯雄、费绳甫治疗痹证的医案医话,将所载处方运用Excel 2019进行中药频次、功效、性味归经及治法统计,运用IBM SPSS Modeler 18.0进行关联规则Apriori算法分析,通过IBM SPSS Statistics 20.0进行聚类分析。结果:纳入的34首处方中,用药频率在50%以上者主要为当归、秦艽、独活、桑枝、茯苓,且以薏苡仁、桑枝用量颇多,最多用至29.84 g,其余多数药物轻取其量,以木香用量最轻微,为1.86 g;高频药效主要为补益、祛风湿和利水渗湿;高频药物的药性以温、平为主,药味以苦、甘、辛为主,归经以肝经、脾经、肾经、胃经为主;常用治法以舒筋通络、养血和荣、利湿渗湿为主;关联分析置信度最高(100%)的是狗脊→当归、续断→当归、大枣→当归、陈皮→当归、木香→当归;聚类分析归为4大类。结论:孟河医派费氏治疗痹证主张以扶正为主,尤以补益营血为首,顾护脾胃中气,注重气血相合,善调肝脾肾,同时兼顾祛邪,以治湿为要,注重给湿邪出路,用药轻灵,以求“轻可去实”,并且提倡药食同源,寓治于调,体现其“醇正和缓”的学术思想。Objective:To explore the Fei’s prescription and medication rules and characteristics in Menghe(孟河)medical school in the treatment of Bizheng(痹证)based on IBM SPSS statistical software.Methods:The medical records and words of Fei Boxiong(费伯雄)and Fei Shengfu(费绳甫)in the Menghe medical school in the treatment of Bizheng were collected,and the recorded prescriptions were analyzed statistically for frequency,functions,Yaoxing(药性),Yaowei(药味),Guijing(归经),and therapy of Chinese medicines by Excel 2019.IBM SPSS modeler 18.0 was used for Apriori algorithm analysis in association rules,and IBM SPSS statistics 20.0 for cluster analysis.Results:In the 34 prescriptions included,the drugs with frequency>50%were mainly Danggui(当归),Qinjiao(秦艽),Duhuo(独活),Sangzhi(桑枝),and Fuling(茯苓).The doses of Yiyiren(薏苡仁)and Sangzhi were the highest,reaching up to 29.84 g,while the doses of other drugs were low,especially Muxiang(木香)whose dose was as low as 1.86 g.In terms of functions,the top three drugs were potent in Buyi(补益),Qufengshi(祛风湿),and Lishuishenshi(利水渗湿).The Yaoxing of high-frequency drugs were mainly Wen(温)and Ping(平),and the Yaowei were mainly Ku(苦),Gan(甘),and Xin(辛).The high-frequency drugs mainly acted on Ganjing(肝经),Pijing(脾经),Shenjing(肾经),and Weijing(胃经).The treatment mainly followed the principles of Shujintongluo(舒筋通络),Yangxueherong(养血和荣),and Lishishenshi(利湿渗湿).As revealed by association rules,the drug pairs with the highest confidence coefficient(100%)were Gouji(狗脊)→Danggui,Xuduan(续断)→Danggui,Dazao(大枣)→Danggui,Chenpi(陈皮)→Danggui,and Muxiang→Danggui.The drugs were classified into four categories according to the cluster analysis.Conclusion:In the treatment of Bizheng,the Fei in the Menghe medical school mainly advocated Fuzheng(扶正),which was dominated by Buyiyingxue(补益营血)and protected Zhongqi(中气)in the Pi(脾)and Wei(胃),highlighted the combination of Qi(�

关 键 词：痹证 用药规律 费伯雄 费绳甫 孟河医派 数据挖掘 

分 类 号：R249[医药卫生—中医临床基础] R255.6[医药卫生—中医学]