药物-药物共晶的设计与制备方法及应用研究进展  

Research Progress on Design,Preparation and Application of Drug-drug Cocrystals

作　　者：王烨阳 袁鹏辉 杨德智[1] 邢逞[1] 张丽[1,2] 吕扬 WANG Yeyang;YUAN Penghui;YANG Dezhi;XING Cheng;ZHANG Li;LYU Yang(Beijing Key Laboratory of Polymorphic Drugs,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Shandong Province Key Laboratory of Polymorphic Drugs,Shandong Yikang Pharmaceutical Co.,Ltd,Tengzhou 277500,China)

机构地区：[1]北京协和医学院、中国医学科学院药物研究所,晶型药物研究北京市重点实验室,北京100050 [2]山东益康药业有限公司,山东省晶型药物重点实验室,滕州277500

出　　处：《医药导报》2023年第7期977-983,共7页Herald of Medicine

基　　金：山东省重点研发计划(2021ZDSYS26);中国医学科学院医学与健康科技创新工程重大协同创新项目(2022-I2M-015);国家自然科学基金资助项目(82141204);新疆维吾尔自治区重点实验室开放课题(2022D04016)。

摘　　要：药物-药物共晶技术作为药物联合治疗的一种新方法,可在不改变药物活性成分化学结构的前提下,优化药物理化性质,发挥协同及双重药物治疗效果,克服传统联合用药中存在的缺陷,成为近年来固体化学药物研究领域备受关注的研究热点。该文综述近些年药物-药物共晶设计预测方法、制备方法与应用优势,可为其后续在药物研发领域的应用提供一定参考。As a new method of drug combination therapy,drug-drug cocrystals can optimize the physicochemical properties of drugs,give play to the synergistic and dual drug therapeutic effects,and overcome the defects in traditional combination drugs without changing the chemical structure of the active components of the drug.In recent years,drug-drug cocrystal has been a hot research topic in solid chemical drug.This paper reviewed the design and prediction methods of drug-drug cocrystal,and the preparation methods and application advantages,to provide some reference for the subsequent application in drug research and development.

关 键 词：药物-药物共晶 制备方法 设计预测 

分 类 号：TQ460.1[化学工程—制药化工]