静电喷雾制备多功能肝癌介入用栓塞微球研究进展  

Research Progress of Electrosprayed Multifunctional Embolic Microspheres for Interventional Embolization of Hepatocellular Carcinoma

作　　者：杜青 李娇娇[1,2] 杨鑫 陈星宇 赵彦兵[1,2] 万江陵 杨祥良[1,2] DU Qing;LI Jiaojiao;YANG Xin;CHEN Xingyu;ZHAO Yanbing;WAN Jiangling;YANG Xiangliang(College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China;National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology,Wuhan 430074,China)

机构地区：[1]华中科技大学生命科学与技术学院,武汉430074 [2]华中科技大学国家纳米药物工程技术研究中心,武汉430074

出　　处：《医药导报》2023年第7期1055-1060,共6页Herald of Medicine

基　　金：国家自然科学基金青年项目(81703077);“3551光谷人才计划”项目(武新管[2017]128号)。

摘　　要：介入治疗是中晚期肝癌的首选治疗方案,血管栓塞材料的栓塞效果直接决定着治疗效果。近年来,随着材料科学、医学影像学、生物医学工程等学科的交叉和发展,开发出了一种基于静电喷雾技术的多功能栓塞微球。通过精确控制微球的尺寸和引入自身显影性,可为肝癌的精准介入治疗打下坚实基础。此外,该制备方法易于引入多种功能物质,为介入治疗与其他治疗方法联用提供便利。该文综述基于静电喷雾技术的多功能栓塞微球的优势,展望功能栓塞微球在肿瘤介入治疗中面临的机遇与挑战。Interventional therapy is the first choice for treating advanced hepatocellular carcinoma(HCC).The embolization effect of embolic material directly determines the therapeutic effect.In recent years,multifunctional embolic microspheres based on electrospray technology have been developed with the development of interdisciplinary subjects including materials science,medical imaging and biomedical engineering.By accurately controlling the size of microspheres and introducing the inherent visibility under medical imaging techniques,it provides a solid foundation for the precise interventional treatment of HCC.In addition,the preparation method is easy to introduce a variety of functional substances,which provides convenience for the combination of interventional therapy and other therapeutic methods.This article reviewed the advantages of multifunctional embolic microspheres fabricated by electrospray technology and looked forward to the opportunities and challenges of functional embolic microspheres in interventional therapy of tumors.

关 键 词：栓塞微球 静电喷雾 自显影微球 肝癌 经导管动脉栓塞 

分 类 号：R95[医药卫生—药学] R979.1