Current advances of biocontainment strategy in synthetic biology  

作　　者：Xueying Zhu Zhaoyang Zhang Bin Jia Yingjin Yuan 

机构地区：[1]Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education),School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

出　　处：《Chinese Journal of Chemical Engineering》2023年第4期141-151,共11页中国化学工程学报（英文版）

基　　金：supported by grants from the National Key Research and Development Program of China (2019YFA0903800);the National Natural Science Foundation of China (31800719 and 21621004)。

摘　　要：Synthetic biotechnology has led to the widespread application of genetically modified organisms(GMOs)in biochemistry, bioenergy, and therapy. However, the uncontrolled spread of GMOs may lead to genetic contamination by horizontal gene transfer, resulting in unpredictable biosafety risks. To deal with these challenges, many effective methods have been developed for biocontainment. In this article, we summarize and discuss recent advances in biocontainment strategies from three aspects: DNA replication, transcriptional regulation, and protein translation. We also briefly introduce the efforts in the biocontainment convention, such as the recent publication of the Tianjin Biosecurity Guidelines for the Code of Conduct for Scientists.

关 键 词：Genetically modified organisms(GMOs) Biocontainment BIOSECURITY Synthetic biology Molecular biology BIOTECHNOLOGY 

分 类 号：Q81[生物学—生物工程]