Microfluidic field strategy for enhancement and scale up of liquid-liquid homogeneous chemical processes by optimization of 3D spiral baffle structure  

作　　者：Shuangfei Zhao Yingying Nie Wenyan Zhang Runze Hu Lianzhu Sheng Wei He Ning Zhu Yuguang Li Dong Ji Kai Guo 

机构地区：[1]College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,China [2]State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing Tech University,Nanjing 211816,China [3]Institute of Nanjing Advanced Biomaterials&Processing Equipment,Nanjing 211299,China

出　　处：《Chinese Journal of Chemical Engineering》2023年第4期255-265,共11页中国化学工程学报（英文版）

基　　金：supported by the National Key Research and Development Program of China (2021YFC2101900 and 2019YFA0905000);National Natural Science Foundation of China (21908094, 21776130 and 22078150);Nanjing International Joint Research and Development Project (202002037);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions。

摘　　要：Due to the scale effect, the uniform distribution of reagents in continuous flow reactor becomes bad when the channel is enlarged to tens of millimeters. Microfluidic field strategy was proposed to produce high mixing efficiency in large-scale channel. A 3D spiral baffle structure(3SBS) was designed and optimized to form microfluidic field disturbed by continuous secondary flow in millimeter scale Y-shaped tube mixer(YSTM). Enhancement effect of the 3SBS in liquid-liquid homogeneous chemical processes was verified and evaluated through the combination of simulation and experiment. Compared with 1 mm YSTM, 10 mm YSTM with 3SBS increased the treatment capacity by 100 times, shortened the basic complete mixing time by 0.85 times, which proves the potential of microfluidic field strategy in enhancement and scale-up of liquid-liquid homogeneous chemical process.

关 键 词：Mixing efficiency Chemical process intensification Scale up REACTOR Computational fluid dynamics(CFD) Numerical simulation 

分 类 号：TQ03[化学工程]