三代口服头孢菌素在大学生下呼吸道感染治疗中的应用效果  

Effect of three generations of oral cephalosporins in the treatment of lower respiratory tract infection in college students

作　　者：吴萌 Wu Meng(Xianning Vocational and Technical College Clinic,Xianning,Hubei 437100,China)

机构地区：[1]湖北省咸宁职业技术学院医务室,湖北咸宁437100

出　　处：《首都食品与医药》2023年第12期77-79,共3页Capital Food Medicine

摘　　要：目的探索第三代头孢菌素药物(头孢曲松与头孢克肟)序贯疗法治疗大学生下呼吸道感染的疗效及安全性。方法将咸宁职业技术学院2021年1月-2022年10月期间收治的下呼吸道感染大学生87例作为研究对象。按照随机分组的原则采用随机数字表法将患者随机分为观察组(n=44例)和对照组(n=43例)。两组患者入院后均完成相关检查,同时给予相应的对症药物治疗,对照组在此基础上增加头孢曲松静脉滴注治疗,观察组采用头孢克肟、头孢曲松序贯疗法治疗,两组患者均连续给药14d后,比较临床有效率,不良反应发生率及治疗前后血清炎症因子水平。结果治疗后,对照组临床有效率为83.72%,观察组临床有效率为95.45%,观察组临床有效率明显高于对照组,差异有统计学意义(χ^(2)=6.287,P<0.05);治疗后,对照组不良反应发生率为16.28%,观察组不良反应发生率为2.27%,观察组不良反应发生率低于对照组,差异有统计学意义(χ^(2)=5.981,P<0.05);治疗前,两组血清IL-6、IL-8、IL-10、CRP水平比较,差异均无统计学意义(均P>0.05),治疗后,两组血清IL-6、IL-8、IL-10、CRP水平均较同组治疗前明显降低,且治疗后观察组各项指标均明显低于对照组,差异均有统计学意义(均P<0.05)。结论急性下呼吸道感染大学生采用头孢克肟与头孢曲松序贯疗法进行治疗效果显著,安全性高,可推广应用。Objective To explore the efficacy and safety of sequential therapy with the third generation cephalosporins(ceftriaxone and cefixime)in the treatment of lower respiratory tract infections in college students.Method 87 college students with lower respiratory tract infection admitted in our hospital from January 2021 to October 2022 were taken as the research objects.According to the principle of random grouping,the patients were randomly divided into the observation group(n=44 cases)and the control group(n=43 cases)by using the random number table method.After admission,both groups of patients completed relevant examinations and received corresponding symptomatic drug treatment.On this basis,the control group received intravenous drip of ceftriaxone.The observation group received sequential therapy of cefixime and ceftriaxone.After 14 days of continuous administration,the clinical efficiency,adverse reaction rate and serum inflammatory factor level before and after treatment were compared between the two groups.Result After treatment,the clinical effective rate of the control group was 83.72%,and that of the observation group was 95.45%.The clinical effective rate of the observation group was significantly higher than that of the control group,with a statistically significant difference(χ^(2)=6.287,P<0.05);after treatment,the incidence of adverse reactions in the control group was 16.28%,and that in the observation group was 2.27%.The incidence of adverse reactions in the observation group was lower than that in the control group,with a statistically significant difference(χ^(2)=5.981,P<0.05);there was no significant difference in the levels of serum IL-6,IL-8,IL-10 and CRP between the two groups before treatment(all P>0.05).After treatment,the levels of serum IL-6,IL-8,IL-10 and CRP in the two groups were significantly lower than those in the same group before treatment,after treatment,the observation group was significantly lower than the control group,and the difference was statistically significant(P<0.05).C

关 键 词：下呼吸道感染 头孢菌素 肺炎 头孢克肟 头孢曲松 

分 类 号：R373.1[医药卫生—病原生物学]