Commercial wound dressings for the treatment of exuding wounds:an in-depth physico-chemical comparative study  

作　　者：Manon Minsart Sandra Van Vlierberghe Peter Dubruel Arn Mignon 

机构地区：[1]Polymer Chemistry&Biomaterials Research Group,Centre of Macromolecular Chemistry,Department of Organic and Macromolecular Chemistry,Ghent University,Krijgslaan 281,Building S4-bis,9000 Ghent,Belgium [2]Smart Polymeric Biomaterials Research Group,Biomaterials and Tissue Engineering(SIEM)@Campus Group T Leuven,Andreas Vesaliusstraat 13,3000 Leuven,Belgium

出　　处：《Burns & Trauma》2022年第1期465-478,共14页烧伤与创伤（英文）

基　　金：MMwould like to thank FondsWetenschappelijk Onderzoek(FWO)for financial support(SB PhD fellow at FWO,Grant No.3SB5619);AM has also received funding from Fonds Wetenschappelijk Onderzoek(Grant No.12Z2918N).

摘　　要：Background:Nowadays,a wide range of wound dressings is already commercially available.The selection of the dressing is of paramount importance as inappropriate wound management and dressing selection can delay the wound healing process.Not only can this be distressing for the patient,but it can also contribute to complications such as maceration and subsequent infection.Many researchers are targeting the design of dressings with superior properties over existing commercial dressings.However,reported results in the state-of-the-art are rarely benchmarked against commercial dressings.The aim of this study was to determine several characteristics of a large variety of the most frequently used commercial wound dressings,providing an overview for both practitioners and researchers.Methods:For this comparative study,11 frequently used commercial wound dressings were selected,representing the different types.The morphology was studied using scanning electron microscopy.The dressings were characterized in terms of swelling capacity(water,phosphate buffered saline and simulated wound fluid),moisture vapour transmission rate(MVTR)and moisture uptake capacity(via dynamic vapour sorption)as well as mechanical properties using tensile testing and texturometry.Results:The selected dressings showed distinctive morphological differences(fibrous,porous and/or gel)which was reflected in the different properties.Indeed,the swelling capacities ranged between 1.5 and 23.2 g/g(water),2.1 and 17.6 g/g(phosphate buffered saline)or 2.9 and 20.8 g/g(simulated wound fluid).The swelling capacity of the dressings in water increased even further upon freeze-drying,due to the formation of pores.The MVTR values varied between 40 and 930 g/m^(2)/24 h.The maximal moisture uptake capacity varied between 5.8%and 105.7%at 95%relative humidity.Some commercial dressings exhibited a superior mechanical strength,due to either being hydrophobic or multi-layered.Conclusions:The present work not only offers insight into a valuable toolbox of suitable wound

关 键 词：Wound dressings BURNS Exuding wounds Wound healing Exudate management PHYSICO-CHEMICAL 

分 类 号：R318.08[医药卫生—生物医学工程]