Challenges and innovations in treating chronic and acute wound infections:from basic science to clinical practice  

作　　者：Xiaotong Ding Qinghan Tang Zeyu Xu Ye Xu Hao Zhang Dongfeng Zheng Shuqin Wang Qian Tan Joanneke Maitz Peter K.Maitz Shaoping Yin Yiwei Wang Jun Chen 

机构地区：[1]School of Pharmacy,Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application,Nanjing University of Chinese Medicine,Nanjing 210023,People’s Republic of China [2]Department of Burns and Plastic Surgery,The affiliated Drum TowHospital of Nanjing University of Chinese Medicine,Nanjing 210008,People’s Republic of China [3]Burns Injury and Reconstructive Surgery Research,ANZAC Research Institute,University of Sydney,Sydney,Australia,2137 [4]Burns Unit,Concord Repatriation General Hospital,Concord,Australia 2137

出　　处：《Burns & Trauma》2022年第1期513-528,共16页烧伤与创伤（英文）

基　　金：supported by National Science Foundation of China(82172217);Fundamental Science(Natural Science)Research Project of the Jiangsu Higher Education Institutions of China(No.21KJB360016);Natural Science Foundation of Nanjing University of Chinese Medicine(No.XZR2020069).

摘　　要：Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality.The underlying mechanism of infections has been widely investigated by scientist,while standard wound management is routinely been used in general practice.However,strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization,delayed healing and drug resistance.In the present review,we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis,non-surgical methods and surgical methods.Moreover,we highlight emerging innovations in the development of antimicrobial peptides,phages,controlled drug delivery,wound dressing materials and herbal medicine,and find that sensitive diagnostics,combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.

关 键 词：Wound infections Skin microbiome Diagnosis Antimicrobial wound dressings Herbal medicine HYDROGELS Antimicrobial peptides PHAGES Drug delivery 

分 类 号：R632[医药卫生—外科学]