面部肿胀性红斑狼疮继发龟分枝杆菌感染一例  

Facial tumescent lupus erythematosus secondary with Mycobacterium chelonae infection: a case report

作　　者：彭一然 孙乐乐[1] 暴芳芳[1] 周桂芝[1] 卢宪梅[1] 刘永霞[1] 刘红[1] 张福仁[1] PENG Yiran;SUN Lele;BAO Fangfang;ZHOU Guizhi;LU Xianmei;LIU Yongxia;LIU Hong;ZHANG Furen(Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venerology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院(山东省皮肤病医院),山东省皮肤病性病防治研究所,山东济南250022

出　　处：《中国麻风皮肤病杂志》2023年第7期512-515,共4页China Journal of Leprosy and Skin Diseases

基　　金：山东省“泰山学者青年专家计划”(编号:tsqn201812124);山东第一医科大学学术提升计划(编号:2019RC007)。

摘　　要：龟分枝杆菌感染可继发于外科手术操作、外伤等,也可能与使用免疫抑制药物相关。临床表现与病理表现缺乏特异性,需抗生素联合足疗程治疗。本文报道一例面部肿胀性红斑狼疮,治疗数天后面部原皮疹部位继发红斑、丘疹、脓疱,通过皮肤组织活检、qPCR测序确诊龟分枝杆菌感染,患者经克拉霉素、利奈唑胺药物联合治疗后好转。Mycobacterium chelae infection can be occurred after surgery or trauma,and may also be related to the use of immunosuppressive medicine.The manifestations lacks of specificity.It requires a combination of antibiotics and a full course of treatment.We report a case of facial tumescent lupus erythematosus complicated with Mycobacterium chelae infection.The diagnosis was confirmed by skin biopsy and qPCR sequencing.The patient was cured by clarithromycin and linezolid.

关 键 词：非典型分枝杆菌 龟分枝杆菌 肉芽肿 测序 克拉霉素 利奈唑胺 

分 类 号：R593.241[医药卫生—内科学] R446.5[医药卫生—临床医学]