The dilemma of cytomegalovirus and hepatitis B virus interaction  

作　　者：Muzammil M.Khan Mukarram J.Ali Hira Hanif Muhammad H.Maqsood Imama Ahmad Javier E.G.Alvarez Maria-Andreea Catana Daryl T.Y.Lau 

机构地区：[1]Department of Medicine,Division of Gastroenterology,Liver Research Center,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA,USA [2]Department of Medicine,North Shore Medical Center,Salem,MA,USA

出　　处：《Gastroenterology Report》2022年第1期108-114,共7页胃肠病学报道（英文）

摘　　要：Hepatitis B virus(HBV)remains a global public health problem despite the availability of effective vaccine and antiviral therapy.Cytomegalovirus(CMV),another hepatotropic virus,is also very prevalent in the general population worldwide.Both HBV and CMV can persist in the host and have potential to reactivate especially with weakened host cellular immunity.Superimposed CMV infection can lead to severe HBV reactivation.The pathogenesis of the co-infection of HBV and CMV remains poorly understood.Studies reported conflicting results regarding the inhibitory effect of CMV on HBV replication.There is an unmet need on the management of co-infection of HBV and CMV;research initiatives dedicated to understanding their interactions are urgently needed.

关 键 词：CMV HBV HBV CMV co-infection CMV reactivation HBV reactivation IgG Avidity test 

分 类 号：R512.62[医药卫生—内科学]