人干扰素α1b联合阿昔洛韦治疗EBV相关性传染性单核细胞增多症的效果及对免疫功能、炎性反应的影响  

Effect of human interferonα1b combined with acyclovir in the treatment of EBV-related infectious mononucleosis and its influences on immune function and inflammatory response

作　　者：马敏 高东莲 MA Min;GAO Donglian(Fu County People's Hospital,Yan'an 727500;Traditional Chinese Medicine Hospital of Jia County,Yulin 719200,China)

机构地区：[1]富县人民医院,陕西延安727500 [2]佳县中医院,陕西榆林719200

出　　处：《临床医学研究与实践》2023年第18期90-93,102,共5页Clinical Research and Practice

摘　　要：目的探讨人干扰素α1b联合阿昔洛韦治疗爱泼斯坦-巴尔病毒(EBV)相关性传染性单核细胞增多症(IM)的临床效果。方法选取2021年10月至2022年10月我院收治的108例EBV相关性IM患儿为研究对象,依据编号的奇偶性将其分为对照组(54例,阿昔洛韦治疗)和观察组(54例,在对照组基础上联合人干扰素α1b辅助治疗)。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗后,观察组的自然杀伤细胞(NK)水平及白细胞分化抗原19阳性(CD19^(+))、白细胞分化抗原4阳性(CD4^(+))、白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4^(+)/CD8^(+))高于对照组,白细胞分化抗原8阳性(CD8^(+))低于对照组(P<0.05)。治疗后,观察组的天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)水平低于对照组(P<0.05)。两组的药物不良反应总发生率比较,差异无统计学意义(P>0.05)。结论人干扰素α1b联合阿昔洛韦治疗EBV相关性IM的效果较佳,且安全性理想,可显著改善患儿的免疫功能、炎症反应,具有重要应用价值。Objective To investigate the clinical effect of human interferonα1b combined with acyclovir in the treatment of Epstein-Barr virus(EBV)-related infectious mononucleosis(IM).Methods A total of 108 children with EBV-related IM admitted in our hospital from October 2021 to October 2022 were selected as the research objects.According to the admission number,the children were divided into control group(54 cases,acyclovir treatment)and observation group(54 cases,combined with human interferonα1b adjuvant therapy on the basis of the control group).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group,while the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).After treatment,the natural killer cell(NK)level,cluster of differentiation 19 positive(CD19^(+)),cluster of differentiation 4 positive(CD4^(+))and cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4^(+)/CD8^(+))in the observation group were higher than those in the control group,while the cluster of differentiation 8 positive(CD8^(+))was lower than that in the control group(P<0.05).After treatment,the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),cretine phosphohykinase(CK)and cretine kinase isoenzymes(CK-MB)in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Human interferonα1b combined with acyclovir has a better effect and ideal safety in treating EBV-related IM,which can significantly improve the immune function and inflammatory response of children,with important application value.

关 键 词：爱泼斯坦-巴尔病毒 传染性单核细胞增多症 人干扰素α1b 阿昔洛韦 

分 类 号：R725.1[医药卫生—儿科]