Occurrence of False-Positive Tests and Cross-reactions Between COVID-19 and Dengue With Implications During Diagnosis:A Mixed Evidence Synthesis  

作　　者：Daniel C.Digwo Chidinma P.Elebe Vincent N.Chigor Stella N.Madueke Christian K.Ezeh Anthony C.Ike 

机构地区：[1]Department of Microbiology,University of Nigeria,Nsukka,Enugu State,Nigeria.

出　　处：《Infectious Microbes & Diseases》2023年第2期64-75,共12页感染微生物与疾病（英文）

摘　　要：This review aimed to assess the occurrence of false-positive serological reaction between dengue and coronavirus disease 2019(COVID-19)and its implications for diagnosis.Evidence syntheses were conducted by systematically reviewing available literature using multiple databases,including Web of Science,PubMed,Google Scholar and medRxiv.Among a total of 16 presented cases from clinical settings,cross-reaction to COVID-19 serological tests was observed in two(12.5%)dengue-positive patients,while 14 patients(87.5%)confirmed positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)showed a cross-reaction with dengue serological tests,leading to misdiagnosis and mismanagement by attending clinicians.Of 1789 SARS-CoV-2-positive sera,cross-reaction to dengue serological tests was observed in 180 sera(10%),which is higher than the cross-reaction observed for SARS-CoV-2 in archived pre-COVID-19 sera positive for a dengue infection(75 of 811,9.2%,P=0.674).Clinicians in tropical regions are therefore advised to interpret serological tests with caution and use a more pragmatic approach to triage these infections.

关 键 词：COVID-19 CROSS-REACTION DENGUE SARS-CoV-2 

分 类 号：R563.1[医药卫生—呼吸系统] R51[医药卫生—内科学]