国产与进口加尼瑞克在促性腺激素释放激素拮抗剂方案中的应用对比  

Comparison on the application of domestic and imported ganirelix in the gonadotropin-releasing hormone antagonist cycles

作　　者：刘悦榴 胡煜 曾晓亭 罗克燕 Liu Yueliu;Hu Yu;Zeng Xiaoting;Luo Keyan(Department of Reproductive Medicine,Departmen of Gynecology and Obesterics,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China)

机构地区：[1]遵义医科大学附属医院生殖医学科,妇产科,贵州遵义563099

出　　处：《遵义医科大学学报》2023年第6期612-616,共5页Journal of Zunyi Medical University

摘　　要：目的比较体外受精-胚胎移植时采用促性腺激素释放激素拮抗剂(GnRH-ant)方案中应用国产加尼瑞克与进口加尼瑞克的疗效及临床妊娠结局。方法回顾性分析遵义医科大学附属医院生殖中心2022年1~8月应用GnRH-ant方案行体外受精/卵胞质内单精子注射(IVF/ICSI)助孕患者共291个周期,根据使用拮抗剂药物不同分为国产组(146周期)和进口组(145周期),分析比较两组患者基本资料、促排卵情况及临床妊娠结局。结果两组患者年龄、抗缪勒管激素(AMH)、基础卵泡刺激素(bFSH)、黄体生成素(bLH)、雌二醇(bE2)水平等一般资料无统计学差异(P>0.05);两组扳机日LH>10 U/L所占比例、获卵数、受精率、优质胚胎数比较均无统计学差异(P>0.05),但国产组卵巢过度刺激综合征(OHSS)的发生率低于进口组(2.05%vs 8.28%,P=0.033);两组新鲜胚胎移植种植率、临床妊娠率、早期流产率比较均无统计学差异(P>0.05)。结论GnRH-ant方案中国产加尼瑞克与进口加尼瑞克具有相似的药物效能,国产加尼瑞克组OHSS发生率低于进口加尼瑞克组,但两组均获得良好的临床妊娠结局。Objective The purpose of this study is to provide an assessment of the efficacy and clinical pregnancy outcome of domestic and imported ganirelix in the process of IVF using gonadotropin-releasing hormone antagonists(GnRH-ant).Methods Our study examined 291 GnRH-ant cycles of in vitro fertilization/intraeytoplasmic sperm injection-embryo transfer from January 2022 to August 2022 in the Affiliated Hospital of Zunyi Medical University,including 146 cycles treated with domestic ganirelix and 145 cycles treated with imported ganirelix.The baseline characteristics of the patients and the clinical outcomes of the two groups were compared.Results No significantly differences were found in age,anti mullerian hormone(AMH),basal follicle stimulating hormone(bFSH),basal luteinizing hormone(bLH),basal estradiol(bE2)and other baseline characteristics(P>0.05).There were no significantly differences in proportion of LH>10 U/L on human chorionic gonadotrophin(hCG)trigger day,number of oocytes,fertilization rate and number of high-quality embryos(P>0.05).The incidence of ovarian hyperstimulation syndrome(OHSS)was significantly lower in domestic group than in imported group(2.05%vs 8.28%,P=0.033).There were no significantly differences in implantation rate,clinical pregnancy rate and early pregnancy loss rate following fresh embryo transfer among the two groups(P>0.05).Conclusion It is well established that domestic and imported ganirelix can achieve comparable efficacy and similar clinical outcomes in GnRH-ant cycles,however imported ganirelix is associated with a significant increase in ovarian hyperstimulation syndromes.

关 键 词：体外受精-胚胎移植 拮抗剂方案 控制性促排卵 加尼瑞克 

分 类 号：R711.6[医药卫生—妇产科学]