基于羧酸衍生物远程γ-C(sp^(3))–H键官能团化研究进展  

Recent progress in remoteγ-C(sp^(3))–H functionalization of carboxylic acid derivatives

作　　者：黄月婷 邹东 Yueting Huang;Dong Zou(Department of Pharmacy,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院药学部,杭州310016

出　　处：《中国科学：化学》2023年第6期932-957,共26页SCIENTIA SINICA Chimica

摘　　要：碳氢键选择性活化是化学领域中最基本和最具挑战性的问题之一,在合成各种生物活性物质中具有重要的作用.羧酸及其衍生物是最易获得的原料之一.通常羧酸的α-和β-C(sp^(3))–H键官能化较为容易,而γ-和δ-C(sp^(3))–H因距离较远则难以官能化.因此,发展简便、高效的方法实现羧酸及其衍生物远程C(sp^(3))–H键官能团化成为近年研究热点之一.本文根据不同的反应分类,综述了近些年在不同催化条件下基于羧酸衍生物的远程γ-C(sp^(3))–H键官能团化反应研究进展,详细讨论了反应底物普适性、反应机理和应用,并对该领域的发展前景和局限性进行了总结.The C–H bond selective activation is one of the most fundamental and challenging problems in chemistry and plays an important role in the synthesis of various bioactive substances.Carboxylic acids and its derivatives are among the most readily available raw materials.In general,theα-andβ-C(sp^(3))–H bonds are easy to functionalize,different from remoteγ-andδ-C(sp^(3))–H bonds which are difficult due to their long distances.Therefore,the development of simple and efficient methods for the remote C(sp^(3))–H bonds functionalization of carboxylic acids and its derivatives has been demonstrated as one of the hot topics of research in recent years.In this review,the progress in remoteγ-C(sp^(3))–H functionalization of carboxylic acid derivatives under different catalytic conditions is summarized.The reaction substrate compatibility,mechanism,applications,advantages,and limitations in this field are also discussed in detail.

关 键 词：C–H键活化 选择性催化 远程γ-C(sp^(3))–H键 羧酸及其衍生物 

分 类 号：O621.251[理学—有机化学]