咪唑磺酸盐β-CD电色谱固定相在混合手性药物拆分中的应用  

Application of imidazole sulfonateβ-CD electrochromatographic stationary phase in the resolution of mixed chiral drugs

作　　者：唐艺旻 赵冰[1,2] 高立娣[1] 秦世丽 李雪[1] TANG Yi-min;ZHAO Bing;GAO Li-di;QIN Shi-li;LI Xue(College of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,China;Heilongjiang Provincial Key Laboratory of Surface Active Agent and Auxiliary,Qiqihar University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔大学黑龙江省表面活性剂与工业助剂重点实验室,黑龙江齐齐哈尔161006

出　　处：《化学研究与应用》2023年第6期1433-1437,共5页Chemical Research and Application

基　　金：国家自然科学基金项目(21978140)资助;黑龙江省重点研发计划指导项目(GZ20210064)资助;黑龙江省表面活性剂与工业助剂重点实验室开放课题项目(BMHXJKF011)资助。

摘　　要：本文以烯丙基咪唑磺酸盐β-CD(AI-β-CD-OTs)为毛细管电色谱固定相,制备一种离子液体修饰的β-CD毛细管电色谱整体柱,建立一种毛细管电色谱-电喷雾-飞行时间/质谱(CEC-ESI-TOF/MS)联用分离分析美托洛尔和特布他林混合手性药物的方法。优化毛细管电色谱(CEC)分离条件及质谱(MS)检测条件,在最佳的CEC分离条件和MS检测条件下,两种混合药物对映体在15 min内实现基线分离,4组分的分离度分别为1.71,4.85,3.68。A method of capillary electrochromatography-electrospray-time-of-flight/mass spectrometry(CEC-ESI-TOF/MS)combined separation and analysis of mixed chiral drug with metoprolol and terbutaline was established using allylimidazolsulfonateβ-CD(AI-β-CD-OTs)as the capillary electrochromatographic stationary phase to prepare an ionic liquid-modifiedβ-CD capillary electrochrom-atographic monolithic column.By optimizing the separation conditions of capillary electrochromatography(CEC)and the detection conditions of mass spectrometry(MS),under optimal CEC separation conditions and MS detection conditions,the two mixed chiral drugs achieved baseline separation within 15 minutes.The resolution of the 4 components was 1.71,4.85,and 3.68,respectively.

关 键 词：离子液体 Β-CD 混合手性药物 对映体拆分 

分 类 号：O657.8[理学—分析化学]