复合型荧光探针I_(3)^(-)-bRhB-CTAB用于头孢噻肟钠含量检测  

Detection of cefotaxime sodium with complex fluorescent probe I_(3)^(-)-bRhB-CTAB

作　　者：靳佩芸 张爱菊 张小林 JIN Pei-yun;ZHANG Ai-jv;ZHANG Xiao-lin(Department of Pharmacy,Gansu Medical College,Pingliang 744000,China)

机构地区：[1]甘肃医学院药学系,甘肃平凉744000

出　　处：《化学研究与应用》2023年第6期1464-1467,共4页Chemical Research and Application

基　　金：2021年甘肃省高等学校创新基金项目(2022A-185)资助。

摘　　要：在pH 5.0弱酸性环境下,十六烷基三甲基溴化铵(CTAB)作增敏剂,依托碘合离子(I_(3)^(-))与丁基罗丹明B(bRhB)的缔合作用,合成一种复合增强型荧光探针I_(3)^(-)-bRhB-CTAB,将探针用于头孢噻肟钠含量检测,头孢噻肟钠浓度在0~0.02000 g·L^(-1)范围内与体系荧光增量(ΔF)之间呈良好的线性关系,检出限为3.200×10^(-5)g·L^(-1)。样品分析的回收率在95.00%~101.0%范围内,RSD=0.70%。A novel fluorescent probe(I_(3)^(-)-bRhB-CTAB)was prepared by association reaction using Butyl Rhodamine B(bRhB)and soluble iodine(I_(3)^(-))as raw materials.Under pH 5.0 weak acid environment.The probe was used for the detection of cefotaxime sodi-um,and the results showed that there was a good linear relationship between the fluorescence release increment(ΔF)and the concentration of cefotaxime sodium in the range of 0~0.02000 g·L^(-1).The detection limits was 3.200×10^(-5)g·L^(-1).The recovery rate of sample analysis was controlled within the range of 95.00%~101.0%,and the relative standard deviation RSD=0.70%.

关 键 词：荧光探针 碘 丁基罗丹明 头孢噻肟钠 

分 类 号：O657.3[理学—分析化学]