亚精胺对EIF5A的hypusine修饰的生理病理功能研究进展  

Advances in the study of spermidine via hypusine modification of EIF5A in physiopathology

作　　者：段兵兵 王方珂 周远飞[1] DUAN Bing-Bing;WANG Fang-Ke;ZHOU Yuan-Fei(College of Animal Sciences&Technology/College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]华中农业大学动物科学技术学院/动物医学院,武汉430070

出　　处：《生命科学》2023年第5期601-608,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(32002187);湖北重点研发计划项目(2020BBA039,2021BBA252)。

摘　　要：亚精胺是生物体内普遍存在的生物活性小分子——多胺家族的一员,具有多种重要的生物学功能,其中最特别的是参与真核翻译起始因子5A (eukaryotic translation initiation factor 5A, EIF5A)的活化,对EIF5A上一个特定赖氨酸残基进行修饰,称为hypusine修饰。目前关于亚精胺通过EIF5A的hypusine修饰对相关生物事件影响的研究备受关注。该文总结了在人生理病理方面亚精胺相关的报道,重点关注亚精胺通过EIF5A的hypusine修饰影响生理病理功能的研究进展,以期为亚精胺在医学和营养健康方面的应用研究提供参考。Spermidine is a member of the polyamine family,a family of biologically active small molecules prevalent in living organisms,and has a variety of important biological functions.The most special one of these functions is its involvement in the activation of eukaryotic translation initiation factor 5A(EIF5A)by modifying a specific lysine residue on the EIF5A molecule,called hypusine modifying effect.Much attention is currently being paid to the study of the effect of spermidine on related biological events through the hypusine modification of EIF5A.This paper summarizes the reports related to spermidine in human physiopathology,focusing on the research progress of spermidine on physiopathology through hypusine modification of EIF5A,in order to provide a reference for research on the application of spermidine in medicine and nutritional health.

关 键 词：亚精胺 真核翻译起始因子5A HYPUSINE 

分 类 号：Q5[生物学—生物化学] R587.1[医药卫生—内分泌] R73[医药卫生—内科学] R741[医药卫生—临床医学]