山羊新型颈椎间盘置换术后颈椎活动度  

Cervical range of motion after novel cervical disc replacement in goats

作　　者：王逢贤[1] 徐林[1] 曲弋[1] 赵赫[1] 曹旭[1] 杨济洲[1] 杨永栋[1] 赵丁岩 俞兴[1] WANG Feng-xian;XU Lin;QU Yi;ZHAO He;CAO Xu;YANG Ji-zhou;YANG Yong-dong;ZHAO Ding-yan;YU Xing(Department of Orthopaedics,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院骨科,北京100700

出　　处：《中国矫形外科杂志》2023年第11期1014-1017,共4页Orthopedic Journal of China

摘　　要：[目的]测量新型国产人工颈椎间盘假体在山羊颈椎的活动度。[方法]12只山羊随机分为3组,每组4只,包括羟基磷灰石(hydroxyapatite,HA)涂层的间盘假体组,非HA涂层的间盘假体组和假手术组。HA组和非HA组动物摘除C3/4间盘并置入相应国产人工颈椎间盘假体,假手术组仅行手术显露,未处理椎间盘。动态测量颈椎整体活动度及置换节段活动度(range of motion,ROM)。[结果]术后动物实验中所有山羊均成活,无切口感染及瘫痪。随时间推移HA组和假手术组的C2~C5ROM和C3/4ROM均无显著变化(P>0.05),而非HA组的C_(2)~C_(5)ROM和C_(3/4)ROM显著减少。术前及术后即刻三组间C_(2)~C_(5)ROM和C_(3/4)ROM的差异均无统计学意义(P>0.05),但术后1和3个月时,HA组和假手术组的C_(2)~C_(5)ROM和C_(3/4)ROM均显著大于非HA组(P<0.05),而HA组与假手术组的C_(2)~C_(5)ROM和C_(3/4)ROM差异无统计学意义(P>0.05)。[结论]HA涂层的新型国产人工颈椎间盘置换术后较好的保持了山羊颈椎的活动度。[Objective]To measure the cervical range of motion(ROM)after cervical disc replacement with a novel prosthesis made in China in goats.[Methods]Twelve goats were randomly divided into 3 groups,including hydroxyapatite(HA)coated intervertebral prosthesis group,non-HA coated intervertebral prosthesis group and sham operation group,with 4 goats in each group.In the HA group and the non-HA group,C_(3/4) disc was removed and the corresponding prosthesis was implanted,while the sham group had surgical exposure performed without intervertebral disc involved.The C_(2)-C_(5),ROM and C_(3/4) ROM were measured regularly by dynamic radigraphs.[Results]All goats survived without incision infection and paralysis in any animal after operation.HA group and sham group remained no significant changes in C_(2)-C_(5) ROM and C_(3/4) ROM over time(P>0.05),whereas the non-HA group had C_(2)-C_(5),ROM and C_(3/4) ROM significantly reduced over time postoperatively(P<0.05).Although there were no significant differences in C_(2)-C_(5),ROM and C3/4 ROM among the 3 groups before and immediately after surgery(P>0.05),the HA group and the sham group had significantly greater C_(2)-C_(5),ROM and C_(3/4) ROM than non-HA group at 1 and 3 months after surgery(P<0.05).However,there was no significant difference in C_(2)-C_(5),ROM and C_(3/4) ROM between HA group and sham group at 1 and 3 months postoperatively(P>0.05).[Conclusion]This novel HA coated intervertebral disc prosthesis made in China does properly maintain the range of motion of cervical spine in goats.

关 键 词：颈椎 人工颈椎间盘置换 国产人工颈椎间盘假体 动物模型 

分 类 号：R687[医药卫生—骨科学]