Effects of orientation and distance of goats on blast lung injury characteristics on a plateau above 4500-meter  

作　　者：Zhao-Xia Duan Guan-Hua Li Jie-Yuan Zhang Meng-Sheng Deng Kui-Jun Chen Liang-Chao Zhang Xiang-Yun Cheng Jing Chen Guang-Ming Yang Jian-Min Wang 

机构地区：[1]Deparment of Weapon Boct Assessment,Research Institute of Surgey,Daping Hospital,Amy Medical Univerity Chongqing,400042,China [2]State Key Laboratory of Trauma,Burn and Combined Injury,Army Medical University,Chongqing,400038,China

出　　处：《Chinese Journal of Traumatology》2023年第3期139-146,共8页中华创伤杂志（英文版）

基　　金：Military Logistic(s)Scientific Research Program of China(ALJ18J001)。

摘　　要：Purpose:High explosives are used to produce blast waves to study their biological effects.The lungs are considered as the critical target organ in blast-effect studies.The degree of lung hemorrhaging is related to both the explosive power and the increased lung weight.We studied the characteristics of the biological effects from an air explosion of a thermobaric bomb in a high-altitude environment and the lethality and lung injury severity of goats in different orientations and distances.Methods:Goats were placed at 2.5,3,4,and 5 m from the explosion center and exposed them to an air blast at an altitude of 4700-meter.A group of them standing oriented to the right side and the other group seated facing the explosion center vertically.The lung injuries were quantified according to the percentage of surface area contused,and using the pathologic severity scale of lung blast injury(PSSLBI)to score the 4 injury categories(slight,moderate,serious and severe)as 1,2,3,and 4,respectively.The lung coefficient(lung weight[g]/body weight[kg])was the indicator of pulmonary edema and was related to lung injury severity.Blast overpressure data were collected using blast test devices placed at matching locations to represent loadings to goats.All statistical analyses were performed using SPSS,version 26.0,statistical software(SPSS,Inc.,Chicago,IL,USA).Results:In total,127 goats were involved in this study.Right-side-standing goats had a significantly higher mortality rate than those seated vertical-facing(p<0.05).At the 2.5 m distance,the goat mortality was nearly 100%,whereas at 5 m,all the goats survived.Lung injuries of the right-side-standing goats were 1-2 grades more serious than those of seated goats at the same distances,the scores of PSSLBI were significantly higher than the seated vertical-facing goats(p<0.05).The lung coefficient of the right-side-standing goats were significantly higher than those of seated vertical-facing(p<0.05).Mortality,PSSLBI,and the lung coefficient results indicated that the right-side-standi

关 键 词：Blast injuries Lung injury PLATEAU 

分 类 号：R826.6[医药卫生—临床医学]