放射根瘤菌的实验室特征及耐药性分析  

Analysis of laboratory characteristics and drug resistance of Rhizobium radiobacter

作　　者：刘军利 乔晓慧 薛建昌 迟峰 盖芳[4] LIU Junli;QIAO Xiaohui;XUE Jianchang;CHI Feng;GE Fang(Catheter Room,Shijiazhuang People's Hospital,Hebei 050000,China;不详)

机构地区：[1]石家庄市人民医院导管室,河北050000 [2]石家庄市人民医院影像中心 [3]河北省胸科医院检验科 [4]石家庄市第五医院超声科

出　　处：《医学动物防制》2023年第6期559-562,共4页Journal of Medical Pest Control

基　　金：河北省医学科学重点课题(20211553)。

摘　　要：目的探讨石家庄市某医院放射根瘤菌的实验室特征及耐药性分析,为临床制定合理的抗菌药物治疗方案提供依据。方法对2020年3月至2022年3月在石家庄市某医院分离出的12株放射根瘤菌进行多项实验室检查,采用Kirby-Bauer(简称K-B)纸片琼脂扩散法对22种常规抗菌药物进行敏感性试验。结果12株放射根瘤菌感染者75.0%有侵入性操作史,91.7%的感染者血清白蛋白降低。药物敏感性试验结果显示,头孢吡肟、头孢噻肟、左氧氟沙星、莫西沙星、亚胺培南、美罗培南、氨曲南和头孢哌酮/舒巴坦敏感性均达到100.0%。对环丙沙星、左氧氟沙星、莫西沙星的敏感率均>90.0%。对头孢吡肟、头孢噻肟、头孢曲松和头孢哌酮/舒巴坦敏感率均>80.0%。对氨基糖苷类阿米卡星的敏感率(83.3%)明显优于庆大霉素(50.0%)。结论放射根瘤菌对多种抗菌药物敏感,治疗应优先选用碳青霉烯类、单环β-内酰胺类和喹喏酮类药物。Objective To explore the laboratory characteristics and analyze the drug resistance of Rhizobium radiobacter in a hospital in Shijiazhuang,so as to provide a basis for the clinical formulation of a reasonal antimicrobial treatment plan.Methods A total of 12 strains of Rhizobium radiobacter isolated from a hospital in Shijiazhuang from March 2020 to March 2022 were subjected to multiple laboratory tests.Kirby-Bauer(K-B)disk AGAR diffusion method was used to test the sensitivity of 22 conventional antibacterials.Results Among the 12 strains of Rhizobium radiobacter infected patients,75.0%had a history of invasive operation,and 91.7%of the infected patients had low serum albumin.The drug sensitivity results showed that the sensitivity of cefepime,cefotaxime,levofloxacin,moxifloxacin,imipenem,meropenem,aztreonam and cefoperazone/sulbactam reached 100.0%.The sensitivity rates of ciprofloxacin,levofloxacin and moxifloxacin were all>90.0%.The sensitivity rates of cefepime,cefotaxime,ceftriaxone and cefoperazone/sulbactam were all>80.0%.The sensitivity rate to aminoglycoside amikacin(83.3%)was significantly higher than that to gentamicin(50.0%).Conclusion Rhizobium radiobacter are sensitive to a variety of antibacterials.Carbapenems,monocyclicβ-lactams and quinolones should be given priority in the treatment of Rhizobium radiobacter.

关 键 词：放射根瘤菌 临床特征 实验室特征 抗菌药物 耐药性 分析 

分 类 号：R378[医药卫生—病原生物学] R446.1[医药卫生—基础医学]