Catalytic enantioselective domino alkenylation-alkynylation of alkenes: stereoselective synthesis of 5–7 membered azacycles and carbocycles  

作　　者：Zhaoming Ma Lantian Sun Jianrong Steve Zhou 

机构地区：[1]State Key Laboratory of Chemical Oncogenomics,Guangdong Provincial Key Laboratory of Chemical Genomics,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen 518055,China [2]Department of Chemistry,Hong Kong Baptist University,Hong Kong,China

出　　处：《Science China Chemistry》2023年第6期1701-1706,共6页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22271007);the Peking University Shenzhen Graduate School;the State Key Laboratory of Chemical Oncogenomics;the Guangdong Provincial Key Laboratory of Chemical Genomics;the Shenzhen Bay Laboratory and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs for JSZ。

摘　　要：Enantioselective domino alkenylation-alkynylation of olefins is achieved for the first time,using terminal alkynes directly as pronucleophiles.The new reaction enables facile construction of azacycles carrying quaternary stereocenters,including 5–7 membered pyrrolidines,piperidines and tetrahydroazepines.Moreover,alkynyl groups in azacyclic products provide a useful handle for derivatization that formed both fused and bridged azabicycles.

关 键 词：membered cycles synthesis 

分 类 号：O643.36[理学—物理化学] O626[理学—化学]