A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging  

作　　者：Xuemei Dong Lixin Sun Ziwen Zhang Tianli Zhu Jie Sun Jinzhu Gao Chengjun Dong Rongchen Wang Xianfeng Gu Chunchang Zhao 

机构地区：[1]Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center,Institute of Fine Chemicals,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China [2]Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China

出　　处：《Science China Chemistry》2023年第6期1869-1876,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22077030,22271092,21977018,82173657);the China Postdoctoral Science Foundation(2021M701196)。

摘　　要：Taking apart in numerous physiological and pathological activities,hydrogen sulfide(H_(2)S)has been selected as an excellent target spot for the early diagnosis of cancer.So far,there are many mature probes that apply single optical imaging to monitor endogenous H_(2)S.Nevertheless,a single modality is not an ideal method to afford accurate diagnostic information in comprehensive biological organisms.Herein,we developed a dual-modal imaging probe BWS.This designed probe showed a specific response to H_(2)S with both chemiluminescence and NIR fluorescence light-up.The concurrence of fluorescence and chemiluminescence signal provided“double insurances”for highly accurate monitoring of H_(2)S.Satisfactorily,this dual-modal imaging probe performed precise visualization of endogenous H_(2)S in living cells and in vivo.We envisaged that this chemiluminescence/fluorescence real-time dual-modality strategy for H_(2)S detection will expand and optimize the multimodal imaging methods for efficient diagnosis and treatment of cancer.

关 键 词：CHEMILUMINESCENCE FLUORESCENCE BODIPY dual-modal imaging H_(2)S 

分 类 号：R318[医药卫生—生物医学工程] O657.3[医药卫生—基础医学]