骨疏方治疗绝经后骨质疏松症及抗氧化应激作用的临床研究  

A clinical study on the effect of Gushu formula on postmenopausal osteoporosis and its anti-oxidative stress effect

作　　者：王晟灏 段波[2] 马志毅[2] WANG Chenghao;DUN Bo;MA Zhiyi

机构地区：[1]湖北中医药大学,湖北武汉430061 [2]武汉市中医医院,湖北武汉430050

出　　处：《中医临床研究》2023年第9期136-141,共6页Clinical Journal Of Chinese Medicine

基　　金：武汉市医学科研项目(WZ19C17)。

摘　　要：目的:观察骨疏方治疗女性绝经后骨质疏松症(Postmenopausal Osteoporosis,PMOP)的临床疗效,并探讨其抗氧化应激介导骨质疏松的作用机制。方法:选取患者共150例,随机分为五组,每组30例。4个治疗组予骨疏方,对照组予阿尔法骨化醇软胶囊。结果:6个月后五组疗效指数均≥70%(P<0.05),治疗组疗效更为显著,与对照组相比差异具有统计学意义(P<0.05)。各组总有效率:肾阳虚组83.33%、肝肾阴虚组90.00%、脾肾阳虚组86.67%、肾虚血瘀组83.33%,对照组73.33%,差异有统计学意义(P<0.05)。五组骨密度均有增加,各组治疗后与治疗前比较差异有统计学意义(P<0.05)。4个治疗组较对照组骨密度增加更加明显,差异有统计学意义(P<0.05)。五组骨代谢相关指标均有不同程度的改善,各组与治疗前比较差异有统计学意义(P<0.05)。4个治疗组较对照组骨代谢相关指标改善更为明显,差异有统计学意义(P<0.05)。五组患者活性氧相关指标均与治疗前相比均有不同程度的改善,差异有统计学意义(P<0.05)。治疗后4个治疗组活性氧指标相比对照组改善更加明显,差异有统计学意义(P<0.05)。五组共有9例受试者发生不良反应,全部耐受未退出试验。结论:骨疏方具有较好的抗氧化应激作用且治疗PMOP具有良好的疗效,及较高的安全性。Objective:To observe the clinical efficacy of Gushu formula(骨疏方)in the treatment of postmenopausal women with osteoporosis,and to explore the mechanism of its anti-oxidative stress-mediated osteoporosis.Methods:A total of 150 patients were selected and randomly divided into 5 groups,with 30 cases in each group.The 4 treatment groups were given Gushu formula,and the control group was given Alphacalcidol Soft Capsules.Results:After 6 months,the curative effect indexes in the five groups were all≥70%(P<0.05).The curative effect in the treatment groups were more significant,and the differences were statistically significant compared with the control group(P<0.05).The total effective rate in each treatment group was:83.33%in the kidney-Yang deficiency group,90.00%in the liver-kidney Yin-deficiency group,86.67%in the spleen-kidney-Yang deficiency group,83.33%in the kidney-deficiency blood stasis group,and 73.33%in the control group,and the differences was statistically significant(P<0.05).The bone mineral density of the 5 groups increased,and the difference was statistically significant in each group after treatment(P<0.05).Compared with the control group,the bone mineral density of the four treatment groups increased more significantly,and the difference was statistically significant(P<0.05).The bone metabolism-related indexes in the 5 groups were improved to varying degrees,and the difference was statistically significant in each group compared with that before treatment(P<0.05).Compared with the control group,the improvement of bone metabolism-related indexes in the four treatment groups was more obvious,and the differences were statistically significant(P<0.05).Compared with before treatment,the reactive oxygen species-related indexes in the 5 groups were improved to different degrees,and the differences were statistically significant(P<0.05).After treatment,the reactive oxygen species indexes in the treatment groups were improved more obviously than those in the control group,and the differences were stati

关 键 词：绝经后骨质疏松症 骨密度 中医药 氧化应激 

分 类 号：R274[医药卫生—中医骨伤科学]