腹主动脉钙化患者AAC评分与TGF-β_(1)、MCP-1、骨密度的关系  

Association of AAC score with TGF-β_(1),MCP-1 and bone mineral density in patients with abdominal aortic calcification

作　　者：叶林[1] 史晨辉[1] 闫小龙[2] 孙昊昊 任谦 王维山[1] Ye Lin;Shi Chen-hui;Yan Xiao-long;Sun Hao-hao;Ren Qian;Wang Wei-shan(Orthopaedic Center,The First Affiliated Hospital of the Medical College,Shihezi University,Shihezi,Xinjiang 832002,China;Department of Preventive Medicine,Medical College,Shihezi University,Shihezi,Xinjiang 832002,China)

机构地区：[1]石河子大学医学院第一附属医院骨科中心,新疆石河子832002 [2]石河子大学医学院预防医学系,新疆石河子832002

出　　处：《中国现代医学杂志》2023年第12期72-78,共7页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:82160423)。

摘　　要：目的探讨腹主动脉钙化(AAC)患者血管钙化程度与转化生长因子β_(1)(TGF-β_(1))、单核细胞趋化蛋白1(MCP-1)水平、骨密度的相关性。方法前瞻性选取2021年5月—2022年3月石河子大学医学院第一附属医院收治的401例AAC患者。依据AAC评分将患者分为无钙化组、轻度钙化组、中度钙化组及重度钙化组,分别有107、107、98和89例。双能X射线检测骨密度T值,酶联免疫吸附试验检测血浆中TGF-β_(1)和MCP-1表达,分析AAC评分与TGF-β_(1)、MCP-1水平及骨密度T值的相关性。结果轻度钙化组、中度钙化组、重度钙化组年龄高于无钙化组(P<0.05);无钙化组、轻度钙化组体质量指数高于重度钙化组(P<0.05),无钙化组与轻度钙化组、中度钙化组体质量指数比较,差异无统计学意义(P>0.05);中度钙化组、重度钙化组高血压、冠心病患病率高于无钙化组(P<0.05),无钙化组与轻度钙化组高血压、冠心病患病率比较,差异无统计学意义(P>0.05)。轻度钙化组、中度钙化组、重度钙化组TGF-β_(1)高于无钙化组(P<0.05),重度钙化组高于轻度钙化组、中度钙化组(P<0.05);轻度钙化组、中度钙化组、重度钙化组MCP-1高于无钙化组(P<0.05),中度钙化组高于轻度钙化组(P<0.05),轻度钙化组与重度钙化组MCP-1比较,差异无统计学意义(P>0.05);轻度钙化组、中度钙化组、重度钙化组骨密度异常检出率高于A组(45.8%)(P<0.05),中度钙化组、重度钙化组高于轻度钙化组。有序多分类Logistic回归分析结果显示:年龄、有高血压、骨密度T值降低是影响血管钙化的危险因素(P<0.05)。Pearson分析结果显示:AAC评分与TGF-β_(1)、MCP-1、年龄呈正相关(r=0.245、0.126和0.651,均P<0.05),与骨密度T值、BMI、呈负相关(r=-0.385和-0.168,均P<0.05),与碱性磷酸酶、血钙、血磷、白蛋白无相关性(r=0.065、0.008、-0.071和0.053,均P>0.05)。结论低骨密度、高龄、血浆TGF-β_(1)、MCP-1水平升高Objective To investigate the association of the degree of vascular calcification with the levels of transforming growth factor-β_(1)(TGF-β_(1))and monocyte chemoattractant protein-1(MCP-1)and bone mineral density(BMD)in patients with abdominal aortic calcification(AAC).Methods A total of 401 AAC patients admitted to the First Affiliated Hospital of the Medical College,Shihezi University from May 2021 to March 2022 were prospectively selected.According to the AAC score,the patients were divided into non-calcification group(107 cases),mild calcification group(107 cases),moderate calcification group(98 cases)and severe calcification group(89 cases).The T-score of BMD was measured via dual-energy X-ray absorptiometry,and the plasma levels of TGF-β_(1) and MCP-1 were measured by enzyme-linked immunosorbent assay(ELISA).The correlations of AAC scores with levels of TGFβ_(1) and MCP-1 and T-scores were analyzed.Results The age of patients in the mild calcification group,moderate calcification group and severe calcification group was higher than that in the non-calcification group(P<0.05).The body mass index of patients in the non-calcification group and the mild calcification group was higher than that in the severe calcification group(P<0.05),while there was no difference in the body mass index among patients in the non-calcification group,mild calcification group and moderate calcification group(P>0.05).The prevalence of hypertension and that of coronary heart disease in the moderate calcification group and severe calcification group were higher than those in the non-calcification group(P<0.05),whereas there was no difference in the prevalence of hypertension and that of coronary heart disease between the non-calcification group and the mild calcification group(P>0.05).The level of TGFβ_(1) in the mild calcification group,the moderate calcification group and the severe calcification group was higher than that in the non-calcification group(P<0.05),while that in the severe calcification group was even higher relat

关 键 词：腹主动脉钙化 转化生长因子β_(1) 单核细胞趋化蛋白MCP-1 骨密度 

分 类 号：R543.1[医药卫生—心血管疾病]